聯絡方式

• 辦公室: 第一教學大樓N1033室
• 實驗室: 第一教學大樓N1028室 (分子醫學實驗室)
• 電話: (07) 3121101 ext. 2791
• 傳真: (07) 3125339
• 電子郵件: wtliao@kmu.edu.tw

 

學經歷

• 輔仁大學食品科學系學士 
• 高雄醫學大學 生物化學研究所 碩士 
• 高雄醫學大 學醫學研究所 博士
• 國家衛生研究院 環職組 博士後研究員 
• 高雄醫學大學生物科技學系 教授 

 

主負責授課科目

• 生物科技導論
• 毒理學
• 疾病的分子機轉與動物模式
• 分子診斷
• 腫瘤生物學特論
• 幹細胞與組織工程特論

 

研究方向

• 化學致癌
• 腫瘤免疫
• 組織工程
• 分子醫學

廖偉廷老師特殊專長為組織體外重建及巨噬細胞免疫調控。主要研究工作為結合基礎科學與臨床醫學領域，探討疾病的分子機轉及抑制策略。廖老師任教至今有超過60篇SCI國際學術論文發表，包含多篇IF超過5分的高影響力論文，及多篇期刊領域排頂尖的論文。在科學上的貢獻包括: (1)以巨噬細胞免疫平衡為中心，探討癌症及發炎疾病之基因調控分子機制，並在體外以組織微環境模式重建這些調控。(2)將上述分子機制，應用在開發皮膚癌，痛風，及感染性疾病之防治策略。

 

近期研究成果

1.       Sun YH, You HL, Narwane M, Koi RX, Kao CL, Yuan SF, Liao WT*, Lu TT*, Hsu SCN*. A half sandwich Ru(II)- p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells. Dalton Trans. 2024 Jul 30;53(30):12620-12626. doi: 10.1039/d4dt01012d. *Corresponding Author

2.       Wang CW, Chiou HC, Chen SC, Wu DW, Lin HH, Chen HC, Liao WT, Lin MH, Hung CH, Kuo CH. Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models. Front Immunol. 2023 Aug 22;14:1225348. doi: 10.3389/fimmu.2023.1225348. eCollection 2023. PMID: 37675120 (IF= 8.786, 43/177 Immunology)

3.       Tseng CC, Sung YW, Chen KY, Wang PY, Yen CY, Sung WY, Wu CC, Ou TT, Tsai WC, Liao WT*, Chen CJ, Lee SC, Chang SJ, Yen JH*. The Role of Macrophages in Connective Tissue Disease-Associated Interstitial Lung Disease: Focusing on Molecular Mechanisms and Potential Treatment Strategies. Int J Mol Sci. 2023 Jul 26;24(15):11995. doi: 10.3390/ijms241511995. PMID: 37569370 (IF= 6.208, 69/296 Biochemistry and Molecular biology) *Corresponding Author

4.       Tsai ML, Hsu SH, Wang LT, Liao WT, Lin YC, Kuo CH, Hsu YL, Feng MC, Kuo FC, Hung CH. Di(2-ethylhexyl) phthalate mediates IL-33 production via aryl hydrocarbon receptor and is associated with childhood allergy development. Front Immunol. 2023 Jul 21;14:1193647. doi: 10.3389/fimmu.2023.1193647. eCollection 2023. PMID: 37545493 (IF= 8.786, 43/177 Immunology)

5.       Hsu SK, Jadhao M, Liao WT, Chang WT, Lin IL, Chiu CC. The Role of Exosomes in Pancreatic Ductal Adenocarcinoma Progression and Their Potential as Biomarkers. Cancers (Basel). 2023 Mar 15;15(6):1776. doi: 10.3390/cancers15061776. PMID: 36980662 (IF=6.575, 76/318 ONCOLOGY)

6.       Hung CH, Hsu HY, Chiou HC, Tsai ML, You HL, Lin YC, Liao WT*, Lin YC*. Arsenic Induces M2 Macrophage Polarization and Shifts M1/M2 Cytokine Production via Mitophagy. Int J Mol Sci. 2022 Nov 10;23(22):13879. doi: 10.3390/ijms232213879. PMID: 36430358 (IF= 6.208, 69/296 Biochemistry and Molecular biology) *Corresponding Author

7.       Li CH, Tsai ML, Chiou HC, Lin YC, Liao WT*, Hung CH*. Role of Macrophages in Air Pollution Exposure Related Asthma. Int J Mol Sci. 2022 Oct 15;23(20):12337. doi: 10.3390/ijms232012337. PMID: 36293195 (IF= 6.208, 69/296 Biochemistry and Molecular biology) *Corresponding Author

8.       Tsai MK, Tsai ML, Wen ZH, Liao WT, Lin YC, Chiou HC, Lin MH, Hung CH. Suppressive Effects of 4-(Phenylsulfanyl) Butan-2-One on CCL-1 Production via Histone Acetylation in Monocytes. Curr Issues Mol Biol. 2022 Oct 3;44(10):4616-4625. doi: 10.3390/cimb44100315. PMID: 36286030 (IF= 2.976, 216/297 BIOCHEMISTRY & MOLECULAR BIOLOGY)

9.       Lin YC, Lin YC, Tsai ML, Liao WT*, Hung CH*. TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes. Cell Biosci. 2022 Mar 15;12(1):32. doi: 10.1186/s13578-022-00767-w. PMID: 35292112 (IF= 9.584, 54/321 =16.8 % BIOCHEMISTRY & MOLECULAR BIOLOGY) *Corresponding Author

10.    Jadhao M, Chen CL, Liu W, Deshmukh D, Liao WT, Chen JY, Urade R, Tsai EM, Hsu SK, Wang LF, Chiu CC. Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells. Biomedicines. 2022 Feb 10;10(2):417. doi: 10.3390/biomedicines10020417. PMID: 35203627 (IF= 4.757, 112/321 BIOCHEMISTRY & MOLECULAR BIOLOGY)

11.    Chang SJ, Toyoda Y, Kawamura Y, Nakamura T, Nakatochi M, Nakayama A, Liao WT, Shimizu S, Takada T, Takeuchi K, Wakai K, Shi Y, Shinomiya N, Chen CJ, Li C, Okada Y, Ichida K, Matsuo H; for Japan Gout Genomics Consortium (Japan Gout). A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility. Hum Cell. 2022 Mar;35(2):767-770. doi: 10.1007/s13577-021-00665-2. Epub 2022 Jan 15. PMID: 35032298 (IF= 4.374, 123/203 CELL BIOLOGY)

12.    Hsu SK, Jadhao M, Liao WT, Chang WT, Hung CT, Chiu CC. Culprits of PDAC resistance to gemcitabine and immune checkpoint inhibitor: Tumour microenvironment components. Front Mol Biosci. 2022 Oct 10;9:1020888. doi: 10.3389/fmolb.2022.1020888. PMID: 36299300 (IF= 6.113, 73/297 BIOCHEMISTRY & MOLECULAR BIOLOGY)

13.    Chen CJ, Hu HM, Liao WT*. Pathophysiology of Inflammatory Bowel Diseases. New Engl J Med. 2021 Apr 8;384(14):1376-1377. doi: 10.1056/NEJMc2101562. (IF= 176.079, 1/329 Medicine, General & Internal) *Corresponding Author

14.    Tsai ML, Tsai YG, Lin YC, Hsu YL, Chen YT, Tsai MK, Liao WT*, Lin YC*, Hung CH*. IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-ssociated Mitophagy. Int J Mol Sci. 2021 Dec 21;23(1):3. doi: 10.3390/ijms23010003. PMID: 35008429 (IF= 6.208, 69/296 Biochemistry and Molecular biology) *Corresponding Author

15.    Liao WT, Hung CH, Liang SS, Yu S, Lu JH, Lee CH, Chai CY, Yu HS. Anti-inflammatory effects induced by near-infrared light irradiation via M2 macrophage polarization.J Invest Dermatol. 2021 Aug; 141(8):2056-2066.e10. doi: 10.1016/j.jid.2020.11.035. PMID: 33676947. (IF= 8.551, 4/92 Dermatology)

16.    Lin CY, Huang CH, Wang WH, Tenhunen J, Hung LC, Lin CC, Chen YC, Chen YH, Liao WT*. Mono-(2-ethylhexyl) phthalate promotes dengue virus infection by decreasing IL-23-mediated anti-viral responses. Front Immunol. 2021 Feb 15;12:599345. doi: 10.3389/fimmu.2021.599345. PMID: 33659001; PMCID: PMC7919524. (IF= 8.786, 43/177 Immunology) *Corresponding Author

17.    Tseng CC, Wong MC, Liao WT*, Chen CJ, Lee SC, Yen JH, Chang SJ (2021, Apr). Genetic Variants in Transcription Factor Binding Sites in Humans: Triggered by Natural Selection and Triggers of Diseases. Int J Mol Sci. 2021 Apr 18;22(8):4187. doi: 10.3390/ijms22084187. PMID: 33919522 (IF= 6.208, 69/296 Biochemistry and Molecular biology) *Corresponding Author

18.    Hung CH, Lin YC, Tsai YG, Lin YC, Kuo CH, Tsai ML, Kuo CH, Liao WT*. Acrylamide Induces Mitophagy and Alters Macrophage Phenotype via Reactive Oxygen Species Generation. Int J Mol Sci. 2021 Feb 8;22(4):1683. doi: 10.3390/ijms22041683. PMID: 33567502; PMCID: PMC7914752. (IF= 6.208, 69/296 Biochemistry and Molecular biology) *Corresponding Author

19.    Tseng CC, Liao WT*, Wong MC, Chen CJ, Lee SC, Yen JH, Chang SJ*. Cell lineage-specific methylome and genome alterations in gout. Aging-US. 2021 Jan 20;13(3):3843-3865. doi: 10.18632/aging.202353. Epub 2021 Jan 20. PMID: 33493135; PMCID: PMC7906142. (IF= 5.955, 51/203 Geriatrics and Gerontology) *Corresponding Author

20.    Cheng MH, Weng JY, Chuang CH, Liao WT, Lai YF, Liu JY, Fang YP. Prolonging the Half-Life of Histone Deacetylase Inhibitor Belinostat via 50 nm Scale Liposomal Subcutaneous Delivery System for Peripheral T-Cell Lymphoma. Cancers (Basel). 2020 Sep 8;12(9):2558. doi: 10.3390/cancers12092558. PMID: 32911820; PMCID: PMC7563358. (IF= 6.575, 79/317 Oncology)

21.    Tseng CC, Wong MC, Liao WT*, Chen CJ, Lee SC, Yen JH, Chang SJ. Systemic Investigation of Promoter-wide Methylome and Genome Variations in Gout. Int J Mol Sci. 2020 Jul 1;21(13):4702. doi: 10.3390/ijms21134702. PMID: 32630231; PMCID: PMC7369819. (IF= 6.208, 69/296 Biochemistry and Molecular biology) *Corresponding Author

22.    Yu S, Liao WT, Lee CH, Chai CY, Yu CL, Yu HS. Immunological dysfunction in chronic arsenic exposure: From subclinical condition to skin cancer. J Dermatol. 2018 Nov;45(11):1271-1277. doi: 10.1111/1346-8138.14620. Epub 2018 Aug 25. PMID: 30144155. (IF= 3.468, 24/92 Dermatology)

23.    Lu JH, Liao WT, Lee CH, Chang KL, Ke HL, Yu HS. ΔNp63 promotes abnormal epidermal proliferation in arsenical skin cancers. Toxicol In Vitro. 2018 Dec;53:57-66. doi: 10.1016/j.tiv.2018.07.011. Epub 2018 Jul 17. PMID: 30026126. (IF= 3.685, 26/100 Toxicology)

24.    Tseng CC, Chen CJ, Yen JH, Huang HY, Chang JG, Chang SJ, Liao WT*. Next-generation sequencing profiling of mitochondrial genomes in gout. Arthritis Res Ther. 2018 Jul 6;20(1):137. doi: 10.1186/s13075-018-1637-5. PMID: 29976239; PMCID: PMC6034246. (IF= 5.607, 8/52 Rheumatology) *Corresponding Author

25.    Chen CJ, Tseng CC, Yen JH, Chang JG, Chou WC, Chu HW, Chang SJ, Liao WT*. ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study. Sci Rep. 2018 Feb 16;8(1):3137. doi: 10.1038/s41598-018-21425-7. PMID: 29453348; PMCID: PMC5816657. (IF= 4.996, 19/134 Multidisciplinary sciences) *Corresponding Author

26.    Hung CH, Wang CC, Suen JL, Sheu CC, Kuo CH, Liao WT, Yang YH, Wu CC, Leung SY, Lai RS, Lin CC, Wei YF, Lee CY, Huang MS, Huang SK. Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma. Sci Rep. 2018 Jan 17;8(1):919. doi: 10.1038/s41598-017-19105-z. PMID: 29343695; PMCID: PMC5772494. (IF=4.996, 19/134 Multidisciplinary sciences)

27.    Liao WT, You HL, Chai CY, Lee CH, Lan CE, Chang SJ, Yu CL, Yu HS. Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen's disease. J Dermatol Sci. 2018 Feb;89(2):191-197. doi: 10.1016/j.jdermsci.2017.10.003. PMID: 29103775. (IF= 5.408, 8/92 Dermatology)

28.    Kuo CH, Yang SN, Tsai YG, Hsieh CC, Liao WT, Chen LC, Lee MS, Kuo HF, Lin CH, Hung CH. Long-acting β2-adrenoreceptor agonists suppress type 1 interferon expression in human plasmacytoid dendritic cells via epigenetic regulation. Pulm Pharmacol Ther. 2018 Feb;48:37-45. doi: 10.1016/j.pupt.2017.10.004. Epub 2017 Oct 5. PMID: 28987803. (IF= 3.282, 130/361 Pharmacology and Pharmacy)

29.    You HL, Chang SJ, Yu HR, Li CC, Chen CH, Liao WT*. Simultaneous detection of respiratory syncytial virus and human metapneumovirus by one-step multiplex real-time RT-PCR in patients with respiratory symptoms. BMC Pediatr. 2017 Mar 27;17(1):89. doi: 10.1186/s12887-017-0843-7. PMID: 28347279; PMCID: PMC5368990. (IF= 2.567, 54/184 Pediatrics) *Corresponding Author

30.    Liao WT, Lu JH, Wang WT, Hung CH, Sheu CC, Huang SK. Epigenetic synergism between interleukin-4 and aryl-hydrocarbon receptor in human macrophages. J Mol Med (Berl). 2017 Apr;95(4):395-404. doi: 10.1007/s00109-016-1493-1. Epub 2016 Nov 25. PMID: 27888289. (IF= 5.606, 42/191 Genetic and Heredity)

31.    Liao WT, Lu JH, Lee CH, Lan CE, Chang JG, Chai CY, Yu HS. An Interaction between Arsenic-Induced Epigenetic Modification and Inflammatory Promotion in a Skin Equivalent during Arsenic Carcinogenesis. J Invest Dermatol. 2017 Jan;137(1):187-196. doi: 10.1016/j.jid.2016.08.017. PMID: 27592797. (IF= 8.551, 4/92 Dermatology)

32.    Tseng CC, Chang SJ, Liao WT, Chan YT, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH. Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study. Sci Rep. 2016 Jun 21;6:28175. doi: 10.1038/srep28175. PMID: 27325143; PMCID: PMC4914943. (IF= 4.996, 19/134 Multidisciplinary sciences)

33.    Lee CH, Hong CH, Liao WT, Yu HS. Differential immunological effects of infrared irradiation and its associated heat in vivo. J Photochem Photobiol B. 2016 Feb;155:98-103. doi: 10.1016/j.jphotobiol.2016.01.006. Epub 2016 Jan 7. PMID: 26774380. (IF= 6.814, 6/76 Biophysics)

34.    Chen CJ, Hsieh MC, Liao WT^#, Chan YT, Chang SJ. Allopurinol and the incidence of bladder cancer: a Taiwan national retrospective cohort study. Eur J Cancer Prev. Eur J Cancer Prev. 2016 May;25(3):216-23. doi: 10.1097/CEJ.0000000000000161. PMID: 25830898. (IF= 2.164, 236/317 Oncology) ^#Co-first author

35.    Liao WT, You HL, Li C, Chang JG, Chang SJ, Chen CJ. Cyclic GMP-dependent protein kinase II is necessary for macrophage M1 polarization and phagocytosis via toll-like receptor 2. J Mol Med (Berl). 2015 May;93(5):523-33. doi: 10.1007/s00109-014-1236-0. Epub 2014 Dec 6. PMID: 25475742 (IF= 5.606, 42/191 Genetic and Heredity)

36.    Lee CC, Chen YT, Chiu CC, Liao WT, Liu YC, David Wang HM. Polygonum cuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents. J Biosci Bioeng. 2015 Apr;119(4):464-9. doi: 10.1016/j.jbiosc.2014.09.008. Epub 2014 Oct 12. PMID: 25311751. (IF= 3.185, 64/164 Food science and Technology)

37.    Huang B, Chiang KH, Yu HS, Chen YL, You HL, Liao WT*. Arsenic modulates posttranslational S-nitrosylation and translational proteome in keratinocytes. ScientificWorldJournal. 2014;2014:360153. doi: 10.1155/2014/360153. Epub 2014 Jul 8. PMID: 25110733; PMCID: PMC4119667. (IF=1.219, 16/55 Multidisciplinary sciences) *Corresponding Author

38.    Chen CC, Yan SH, Yen MY, Wu PF, Liao WT, Huang TS, Wen ZH, David Wang HM. Investigations of kanuka and manuka essential oils for in vitro treatment of disease and cellular inflammation caused by infectious microorganisms. J Microbiol Immunol Infect. 2016 Feb;49(1):104-11. doi: 10.1016/j.jmii.2013.12.009. Epub 2014 Feb 28. PMID: 24582465. (IF= 10.273, 28/177 Immunology)

39.    Chen CH, Wang CZ, Wang YH, Liao WT, Chen YJ, Kuo CH, Kuo HF, Hung CH. Effects of Low-Level Laser Therapy on M1-related Cytokine Expression in Monocytes via Histone Modification . Mediators Inflamm. 2014;2014:625048. doi: 10.1155/2014/625048. Epub 2014 Feb 19. PMID: 24692853; PMCID: PMC3945284. (IF= 4.529, 115/177 Immunology)

40.    Lee CC, Chiu CC, Liao WT, Wu PF, Chen YT, Huang KC, Chou YT, Wen ZH, Wang HM. Alpinia oxyphylla Miq. bioactive extracts from supercritical fluid carbon dioxide extraction. Biochemical Engineering Journal. 2013 Sep 15;78:101– 7. doi:10.1016/j.bej.2013.03.009 (IF= 4.446, 52/167 Biotechnology and Applied microbiology)

41.    Hung CH, Yang SN, Wang YF, Liao WT, Kuo PL, Tsai EM, Lee CL, Chao YS, Yu HS, Huang SK, Suen JL. Environmental alkylphenols modulate cytokine expression in plasmacytoid dendritic cells. PLoS One. 2013 Sep 11;8(9):e73534. doi: 10.1371/journal.pone.0073534. PMID: 24039973; PMCID: PMC3770601. (IF= 3.752, 28/134 Multidisciplinary sciences)

42.    Liang SS, Liao WT, Kuo CJ, Chou CH, Wu CJ, Wang HM. Phthalic Acid chemical probes synthesized for protein-protein interaction analysis. Int J Mol Sci. 2013 Jun 24;14(7):12914-30. doi: 10.3390/ijms140712914. PMID: 23797655; PMCID: PMC3742165. (IF= 6.208, 69/296 Biochemistry and Molecular biology)

43.    Liang SS, Shiue YL, Kuo CJ, Guo SE, Liao WT, Tsai EM. Online monitoring oxidative products and metabolites of nicotine by free radicals generation with fenton reaction in tandem mass spectrometry. ScientificWorldJournal. 2013 Jul 25;2013:189162. doi: 10.1155/2013/189162. PMID: 23983622; PMCID: PMC3745948. (IF=1.219, 16/55 Multidisciplinary sciences)

44.    You HL, Lin TM, Wang JC, Li CC, Chao TL, Liao WT, Eng HL. Mannose-binding Lectin Gene Polymorphisms and Mycobacterial Lymphadenitis in Young Patients. Pediatr Infect Dis J. 2013 Sep;32(9):1005-9. doi: 10.1097/INF.0b013e31829e6798. PMID: 24008740. (IF= 3.806, 66/177 Immunology)

45.    Lee CH, Hong CH, Yu WT, Chuang HY, Huang SK, Chen GS, Yoshioka T, Sakata M, Liao WT, Ko YC, Yu HS. Mechanistic correlations between two itch biomarkers, IL-31 cytokine and beta-endorphin neuropeptide, via STAT3/calcium axis in atopic dermatitis. Br J Dermatol. 2012 Oct;167(4):794-803. doi: 10.1111/j.1365-2133.2012.11047.x. PMID: 22578170; PMCID: PMC3482403. (IF= 11.113, 3/92 Dermatology)

46.    Liao WT, Huang TS, Chiu CC, Pan JL, Liang SS, Chen BH, Chen SH, Liu PL, Wang HC, Wen ZH, Wang HM, Hsiao SW. Biological Properties of Acidic Cosmetic Water from Seawater. Int J Mol Sci. 2012;13(5):5952-71. doi: 10.3390/ijms13055952. Epub 2012 May 16. PMID: 22754342; PMCID: PMC3382787. (IF= 6.208, 69/296 Biochemistry and Molecular biology)

47.    Lee CH, Hong CH, Yu CL, Wang LF, Clausen BE, Liao WT, Huang SK, Chen GS, Yu HS. Arsenic mobilizes Langerhans cell migration and induces Th1 response in epicutaneous protein sensitization via CCL21: A plausible cause of decreased Langerhans cells in arsenic-induced intraepithelial carcinoma. Biochem Pharmacol. 2012 May 1;83(9):1290-9. doi: 10.1016/j.bcp.2012.01.028. Epub 2012 Feb 1. PMID: 22321510. (IF= 6.100, 26/361 PHARMACOLOGY & PHARMACY)

48.    Lee CC, Liao WT, Yu HS. Aberrant immune responses in arsenical skin cancers. Kaohsiung J Med Sci. 2011 Sep;27(9):396-401. doi: 10.1016/j.kjms.2011.05.007. Epub 2011 Jul 6. PMID: 21914527. (IF= 2.996, 109/195 Medicine, research, and experiment)

49.    Liao WT, Lan CE, Lee CC, Yu HS. Concentration-dependent cellular responses of arsenic in keratinocytes. Kaohsiung J Med Sci. 2011 Sep;27(9):390-5. doi: 10.1016/j.kjms.2011.05.006. Epub 2011 Aug 9. PMID: 21914526. (IF= 2.996, 109/195 Medicine, research, and experiment)

50.    Lee CH, Wu SB, Hong CH, Liao WT, Wu CY, Chen GS, Wei YH, Yu HS. Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol. 2011 May;178(5):2066-76. doi: 10.1016/j.ajpath.2011.01.056. PMID: 21514422; PMCID: PMC3081159. (IF= 5.770, 9/89 Pathology)

51.    Lee CH, Liao WT, Yu HS. Mechanisms and immune dysregulation in arsenic skin carcinogenesis. Journal of Cancer Therapy. 2010 June;1(2):76-86. doi:10.4236/jct.2010.12013

52.    Liao WT, Yu HS, Arbiser JL, Hong CH, Govindarajan B, Chai CY, Shan WJ, Lin YF, Chen GS, Lee CH. Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids. Exp Dermatol. 2010 Aug;19(8):e142-50. doi: 10.1111/j.1600-0625.2009.01021.x. PMID: 20100200. (IF= 4.511, 15/68 Dermatology)

53.    Liao WT, Yu HS, Lin P, Chang LW. Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Toxicol Appl Pharmacol. 2010 Feb 15;243(1):55-62. doi: 10.1016/j.taap.2009.11.012. Epub 2009 Nov 27. PMID: 19931552. (IF= 4.460, 13/100 Toxicology)

54.    Lee CH, Hu WP, Hong CH, Yu HS, Liao WT, Chen CY, Chen YL, Chen BH, Chen GS, Wang JJ. Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo. Chem Biol Interact. 2009 Aug 14;180(3):360-7. doi: 10.1016/j.cbi.2009.05.001. Epub 2009 May 9. PMID: 19433078. (IF= 5.168, 64/361 PHARMACOLOGY & PHARMACY)

55.    Liao WT, Yu CL, Lan CC, Lee CH, Chang CH, Chang LW, You HL, Yu HS. Differential effects of arsenic on cutaneous and systemic immunity: focusing on CD4+ cell apoptosis in patients with arsenic-induced Bowen's disease. Carcinogenesis. 2009 Jun;30(6):1064-72. doi: 10.1093/carcin/bgp095. Epub 2009 Apr 17. PMID: 19376847. (IF= 4.741, 83/317 Oncology)

56.    Liao WT, Lin P, Cheng TS, Yu HS, Chang LW. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. Toxicol Appl Pharmacol. 2007 Dec 1;225(2):162-70. doi: 10.1016/j.taap.2007.07.017. Epub 2007 Aug 8. PMID: 17945324. (IF= 4.460, 13/100 Toxicology)

57.    You HL, Eng HL, Hsu SF, Chen CM, Ye TC, Liao WT, Huang MY, Baer R, Cheng JT. A PKC-Sp1 signaling pathway induces early differentiation of human keratinocytes through upregulation of TSG101. Cell Signal. 2007 Jun;19(6):1201-11. doi: 10.1016/j.cellsig.2007.01.014. Epub 2007 Jan 20. PMID: 17321722. (IF= 4.850, 106/203 Cell biology)

58.    Yu HS, Liao WT, Chai CY. Arsenic carcinogenesis in the skin. J Biomed Sci. 2006 Sep;13(5):657-66. doi: 10.1007/s11373-006-9092-8. Epub 2006 Jun 29. PMID: 16807664. (IF= 12.771, 30/195 Medicine, Research & Experimental)

59.    Lee CH, Chen JS, Sun YL, Liao WT, Zheng YW, Chai CZ, Chen GS, Yu HS. Defective beta1-integrins expression in arsenical keratosis and arsenic-treated cultured human keratinocytes. J Cutan Pathol. 2006 Feb;33(2):129-38. doi: 10.1111/j.0303-6987.2006.00361.x. PMID: 16420308. (IF= 1.458, 62/89 Pathology)

60.    Lee CH, Yu CL, Liao WT, Kao YH, Chai CY, Chen GS, Yu HS. Effects and interactions of low doses of arsenic and UVB on keratinocyte apoptosis. Chem Res Toxicol. 2004 Sep;17(9):1199-205. doi: 10.1021/tx049938m. PMID: 15377153. (IF= 3.973, 32/72 Chemistry, Medicinal)

61.    Liao WT, Chang KL, Yu CL, Chen GS, Chang LW, Yu HS. Arsenic induces human keratinocyte apoptosis by the FAS/FAS ligand pathway, which correlates with alterations in nuclear factor-kappa B and activator protein-1 activity. J Invest Dermatol. 2004 Jan;122(1):125-9. doi: 10.1046/j.0022-202X.2003.22109.x. PMID: 14962100. (IF= 8.551, 4/92 Dermatology)

62.    Lan CC, Yu HS, Liao WT, Hsu RC, Chung JC, Tsai KB, Chen GS. Clear cell eccrine porocarcinoma with extensive cutaneous metastasis and peripheral lymphocyte dysfunction. Br J Dermatol. 2003 Nov;149(5):1059-63. doi: 10.1111/j.1365-2133.2003.05638.x. PMID: 14632816. (IF= 11.113, 3/92 Dermatology)

63.    Chang KL, Liao WT, Yu CL, Lan CC, Chang LW, Yu HS. Effects of gallium on immune stimulation and apoptosis induction in human peripheral blood mononuclear cells. Toxicol Appl Pharmacol. 2003 Dec 1;193(2):209-17. doi: 10.1016/j.taap.2003.07.004. PMID: 14644623. (IF= 4.460, 25/94 Toxicology) 

64.    Yu HS, Liao WT, Chang KL, Yu CL, Chen GS. Arsenic induces tumor necrosis factor alpha release and tumor necrosis factor receptor 1 signaling in T helper cell apoptosis.J Invest Dermatol. 2002 Oct;119(4):812-9. doi: 10.1046/j.1523-1747.2002.00475.x. PMID: 12406325. (IF= 8.551, 4/92 Dermatology)

Book:

Yu H-S and Liao W-T (2011) Gallium: Environmental pollution and health effects. In: Nriagu JO (ed.) Encyclopedia of Environmental Health, volume 2, pp. 829–833 Burlington: Elsevier.

 

Journal Editor:

Associate Editor, Gout and Hyperuricemia (Elsevier)

 

專利

電解酸性水及其組成物 (證書號 I435951)

用於治療砷誘發之肺功能損傷之類黃酮藥物 (專利證號 111109359)

 

近二年研究成果簡介