Chen YF


  • 辦公室: 第一教學大樓N1030室
  • 實驗室: 第一教學大樓N1024室
  • 電話: (07) 3121101 ext. 2730
  • 傳真: (07) 3125339
  • 電子郵件:
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  • 台灣大學動物系學士(1991) 
  • 台灣大學動物所碩士(1993)  
  • 美國俄亥俄州立大學分子遺傳所碩士(1998) 
  • 國防醫學大學生命科學所博士(2004)


  • 分子細胞生物學 
  • 遺傳學 
  • 腫瘤生物學 
  • 發生生物學
  • 基因體學


  •  口腔癌化療抗藥性相關分子機制。
  •  嚼食檳榔誘發口腔癌之致病機轉及鑑定相關生物標記與治療標靶。
  •  檳榔成癮之分子機制及化學預防。


  • Wang LF, Chien CY, Yang YH, Hour TC, Yang SF, Chen HR, Tsai KL, Ko JY,Chen JYF*COX-2 expression in nasal polyps: a novel insight into the inflammationRhinology, 53(3):270-276. (IF: 3.761; R/C= 1/44, Otorhinolaryngology )
  • Chen JYF, Hour TC, Yang SF, Chien CY, Chen HR, Tsai KL, Ko JY, Wang LF* (2015). Autophagy is deficient in nasal polyps: implications for the pathogenesis of the disease. International Forum of Allergy & Rhinology, 5(2):119-23.
  • Hung CC, Chien CY, Chiang WF, Lin CS, Hour TC, Chen HR, Wang LF, Ko JY, Chang CH, Chen JYF* (2015). p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. Oncotarget, 6(6):4110-25. (IF: 6.627; R/C=17/203, Oncology)
  • Chiang WF, Hwang TZ, Hour TC, Wang LH, Chiu CC, Chen HR, Wu YJ, Wang CC, Wang LF, Chien CY, Chen JH, Hsu CT, Chen JYF* (2013). Calreticulin, an endoplasmic reticulum-resident protein, is highly expressed and essential for cell proliferation and migration in oral squamous cell carcinoma. Oral Oncology, 49: 534-541. (IF: 3.607; R/C=6/88, Dentistry, Oral Surgery and Medicine)
  • Chiang WF, Ho HC, Chang HY, Chiu CC, Chen YL, Hour TC, Chuang SJ,Wu YJ, Chen HR, Chen JH, Liu SY, Lu CL, Chen JYF* (2011). Overexpression of Rho GDP-dissociation inhibitor alphapredicts poor survival in oral squamous cell carcinoma. Oral Oncology, 47: 452-458.(IF: 3.607; R/C=6/88, Dentistry, Oral Surgery and Medicine)
  •  Chiu CC, Chen BH, Hour TC, Chiang WF, Wu YJ, Chen CY, Chen HR, Chan PT, Liu SY, Chen JYF* (2010). Betel quid extract promotes oral cancer cell migration by activating a muscarinic M4 receptor-mediated signaling cascade involving SFKs and ERK1/2. BBRC, 399: 60-65.
  • Chen JYF, Hwang CC, Chen WY, Lee JC, Fu TF, Fang K, Chu YC, Huang YL, Lin JC, Tsai WH, Chang HW, Chen BH, Chiu CC (2010). Additive effects of C2-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. Life Sciences,87: 350-357.
  • Huang CY#, Chen JYF#, Wu JE, Pu YS, Liu GY, Pan MH, Huang YT, Huang AM, Hwang CC, Chung SJ, Hour TC (2010). Ling-Zhi polysaccharides potentiate cytotoxic effects of anti-cancer drugs against drug-resistant urothelial carcinoma cells. Journal of Agricultural and Food Chemistry,58: 8798–8805. (#equal contribution)
  • Tseng MY, Liu SY, Chen HR, Wu YJ, Chiu CC, Chan PT, Chiang WF, Liu YC, Lu CY, Jou YS, Chen JYF* (2009). Serine Protease Inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma. Oral Oncology, 45: 771-776. (IF: 3.607; R/C=6/88, Dentistry, Oral Surgery and Medicine)
  • Chen JYF, Hung CC, Huang KL, Chen YT, Liu SY, Chiang WF, Chen HR, Yen CY, Chung TT, Ko JY, Jou YS (2008). Src family kinases mediate betel quid-induced oral cancer cell motility and could be crucial for the early progression of oral carcinogenesis. Neoplasia, 10(12): 1392-1401. (IF: 5.946; R/C=22/196, Oncology)
  • Liu SY, Chen YT, Tseng MY, Hung CC, Chiang WF, Chen HR, Shieh TY, Chen CH, Jou YS, Chen JYF* (2008). Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: a novel biological function of MAP2 in non-neuronal cells. BBRC, 366(2): 520-525.
  •  Chen JYF, Chang YL, Yu YC, Chao CC, Kao HW, Wu CT, Lin WC, Ko JY, Jou YS (2004). Specific induction of the high-molecular-weight microtubule-associated protein 2 (hmw-MAP2) by betel quid extract in cultured oral keratinocytes: clinical implications in betel quid-associated oral squamous cell carcinoma (OSCC). Carcinogenesis, 25: 269-276. (IF: 5.375, Oncology)
  • Wilkinson B, Chen JYF, Han P, Rufner KM, Goularte OD, Kaye J (2002). TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nature Immunology, 3(3): 272-280. (IF: 27.868, Immunology)
  •  Chen JYF, Stands L, Staley JP, Jackups RR Jr, Latus LJ, Chang TH (2001). Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor. Molecular Cell, 7(1): 227-232. (IF: 16.611, Biochemistry & Molecular Biology)


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