Liao WT-280x202

 

聯絡方式

  • 辦公室: 第一教學大樓N1033室
  • 實驗室: 第一教學大樓N1028室 (分子醫學實驗室)
  • 電話: (07) 3121101 ext. 2791
  • 傳真: (07) 3125339
  • 電子郵件: wtliao@kmu.edu.tw

學經歷

  • 輔仁大學食品科學系學士 (1992/9-1996/6)
  • 高雄醫學大學生物化學研究所碩士 (1996/9-1998/6)
  • 高雄醫學大學醫學研究所哲學博士 (1998/9-2004/6)
  • 國家衛生研究院環職組博士後研究員 (2004/10-2008/10)
  • 高雄醫學大學生物科技學系助理教授 (2010/08-2016/01)
  • 高雄醫學大學生物科技學系副教授 (2016/02-)

主負責授課科目

  • 生物科技導論
  • 腫瘤生物學特論
  • 分子診斷
  • 毒理學
  • 組織工程特論

 

研究方向

  • 化學致癌
  • 腫瘤免疫
  • 組織工程
  • 分子醫學

廖偉廷老師於 2010年8月加入高雄醫學大學生技系,特殊專長為皮膚組織體外重建及巨噬細胞免疫調控。主要研究工作含括環境醫學/免疫/分子生物/基因體/組織工程/動物模式及轉譯方面,連結基礎,臨床及環境三大領域的研究模式,探討疾病的分子機轉及抑制策略。廖老師任教至今(2017.7)有36篇SCI學術論文發表,包含數篇領域第一名的期刊,及影響因子超過5分的期刊。在科學上的貢獻包括: (1)發現皮膚砷癌之病理機制、基因調控以及在體外重建此癌組織以探討其抑制策略。(2)鑑定痛風致病基因cGKII的功能,及其在巨噬細胞發炎的調控。

在科學面前,我們都像學步的嬰孩,快樂而謹慎的驗證,踏下每一步的真實性。歡迎加入本實驗室。

近期研究成果

  1. Liao WT, Lu JH, Lee CH, Lan CE, Chang JG, Chai CY, Yu HS. An Interaction between Arsenic-Induced Epigenetic Modification and Inflammatory Promotion in a Skin Equivalent during Arsenic Carcinogenesis. J Invest Dermatol. 2017 Jan;137(1):187-196. (IF: 7.216; 1/63)
  2. Liao WT, Lu JH, Wang WT, Hung CH, Sheu CC, Huang SK. Epigenetic synergism between interleukin-4 and aryl-hydrocarbon receptor in human macrophages. J Mol Med (Berl). 2017 Apr;95(4):395-404. (IF: 5.107; 27/167)
  3. You HL, Chang SJ, Yu HR, Li CC, Chen CH, *Liao WT. Simultaneous detection of respiratory syncytial virus and human metapneumovirus by one-step multiplex real-time RT-PCR in patients with respiratory symptoms. BMC Pediatr. 2017 Mar ;17(1):89. (IF: 1.813; 45/120)
  4. Tseng CC, Chang SJ, Liao WT, Chan YT, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH. Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study. Sci Rep. 2016 Jun 21;6:28175. (IF: 5.228; 10/64)
  5. Lee CH, Hong CH, Liao WT, Yu HS. Differential immunological effects of infrared irradiation and its associated heat in vivo. J Photochem Photobiol B. 2016 Feb 7;155:98-103. (IF: 2.960; 30/73)
  6. Chen CJ*, Hsieh MC*, Liao WT*, Chan YT, Chang SJ. Allopurinol and the incidence of bladder cancer: a Taiwan national retrospective cohort study. Eur J Cancer Prev. 2016 May; 25(3): 216-223. (IF: 3.031; 95/211)
  7. Liao WT, You HL, Li C, Chang JG, Chang SJ, Chen CJ. Cyclic GMP-dependent protein kinase II is necessary for macrophage M1 polarization and phagocytosis via toll-like receptor 2. J Mol Med (Berl). 2015 May;93(5):523-33. (IF: 5.107; 27/167)
  8. Lee CC, Chen YT, Chiu CC, Liao WT, Liu YC, David Wang HM. Polygonumcuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents. J BiosciBioeng.2014 Oct 11.pii: S1389-1723(14)00343-0. doi: 10.1016/j.jbiosc.2014.09.008. 2015; 119: 464-469.(IF: 1.884; 39/123)
  9. Huang B, Chiang KH, Yu HS, Chen YL, You HL, *Liao WT. Arsenic modulates posttranslational S-nitrosylation and translational proteome in keratinocytes. Scientific World Journal. 2014;2014:360153. Epub 2014 Jul 8. (IF: 1.219; 16/55)
  10. Chen CC, Yan SH, Yen MY, Wu PF, Liao WT, Huang TS, Wen ZH, David Wang HM. Investigations of kanuka and manuka essential oils for in vitro treatment of disease and cellular inflammation caused by infectious microorganisms. J Microbiol Immunol Infect. 2014 Feb 27.pii: S1684-1182(13)00246-6. (IF: 2.349; 69/119)
  11. Chia-Hsin Chen, Chau-Zen Wang, Yan-Hsiung Wang, Wei-Ting Liao, Yi-Jen Chen, Chang-Hung Kuo, Hsuan-Fu Kuo, and Chih-Hsing Hung. Effects of Low-Level Laser Therapy on M1-related Cytokine Expression in Monocytes via Histone Modification. Mediators of Inflammation. 2014;2014:625048. (IF: 3.236; 58/148)
  12. Chih-Chen Lee, Chien-Chih Chiu, Wei-Ting Liao, Pei-Fang Wu, Yen-Ting Chen,Kuo-Chuan Huang, Yi-Ting Chou, Zhi-Hong Wen, Hui-Min Wang. AlpiniaoxyphyllaMiq.bioactive extracts from supercritical fluid carbon dioxide extraction. Biochemical Engineering Journal 78 (2013) 101– 107. (IF: 2.467; 32/135)
  13. Hung CH, Yang SN, Wang YF, Liao WT, Kuo PL, Tsai EM, Lee CL, Chao YS, Yu HS, Huang SK, Suen JL. Environmental alkylphenols modulate cytokine expression in plasmacytoid dendritic cells. PLoS One. 2013 Sep 11;8(9):e73534. (IF: 3.234; 9/57)
  14. Liang SS, Liao WT, Kuo CJ, Chou CH, Wu CJ, Wang HM. Phthalic Acid chemical probes synthesized for protein-protein interaction analysis. Int J Mol Sci. 2013 Jun;14(7):12914-1230. (IF: 2.862; 46/157)
  15. Liang SS, Shiue YL, Kuo CJ, Guo SE, Liao WT, Tsai EM. Online monitoring oxidative products and metabolites of nicotine by free radicals generation with fenton reaction in tandem mass spectrometry. Scientific World Journal.2013 Jul;2013:189162. (IF: 1.219; 16/55)
  16. You HL, Lin TM, Wang JC, Li CC, Chao TL, Liao WT, Eng HL. Mannose-binding Lectin Gene Polymorphisms and Mycobacterial Lymphadenitis in Young Patients. Pediatr Infect Dis J. 2013 Sep;32(9):1005-1009. (IF: 2.723; 19/120)
  17. Lee CH, Hong CH, Yu WT, Chuang HY, Huang SK, Chen GS, Yoshioka T, Sakata M, Liao WT, Ko YC, Yu HS. Mechanistic correlations between two itch biomarkers, IL-31 cytokine and beta-endorphin neuropeptide, via STAT3/calcium axis in atopic dermatitis. Br J Dermatol. 2012 Oct;167(4):794-803. (IF: 4.275; 6/63)
  18. Liao WT, Huang TS, Chiu CC, Pan JL, Liang SS, Chen BH, Chen SH, Liu PL, Wang HC, Wen ZH, Wang HM, Hsiao SW. Biological Properties of Acidic Cosmetic Water from Seawater. Int J Mol Sci. 2012; 13:5952-5971. (IF: 2.862; 46/157)
  19. Lee CH, Hong CH, Yu CL, Wang LF, Clausen BE, Liao WT, Huang SK, Chen GS, Yu HS. Arsenic mobilizes Langerhans cell migration and induces Th1 response in epicutaneous protein sensitization via CCL21: A plausible cause of decreased Langerhans cells in arsenic-induced intraepithelial carcinoma. Biochem Pharmacol. 2012 Feb 1.83(9):1290-9. (IF: 5.009; 23/255)
  20. Lee CC, Liao WT, Yu HS. Aberrant immune responses in arsenical skin cancers.Kaohsiung J Med Sci. 2011; 27: 396-402. (IF: 0.803; 107/123)
  21. Liao WT, Lan CE, Lee CC, Yu HS. Concentration-dependent cellular responses of arsenic in keratinocytes. Kaohsiung J Med Sci.2011; 27: 390-395. (IF: 0.803; 107/123)
  22. Lee CH, Wu SB, Hong CH, Liao WT, Wu CY, Chen GS, Wei YH, Yu HS. Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol.2011; 178: 2066-2076. (IF: 5.224; 10/76)
  23. Lee CH, Liao WT, Yu HS. Mechanisms and immune dysregulation in arsenic skin carcinogenesis. Journal of Cancer Therapy. 2010; 1: 76-86.
  24. Liao WT, Yu HS, Arbiser JL, Hong CH, Govindarajan B, Chai CY, Shan WJ, Lin YF, Chen GS, Lee CH. Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids. Exp Dermatol. 2010; 19:e142-150. (IF: 3.762; 7/63)
  25. Liao WT, Yu HS, Lin P, Chang LW. Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Toxicol Appl Pharmacol. 2010; 243:55-62. (IF: 3.705; 15/88)
  26. Lee CH, Hu WP, Hong CH, Yu HS, Liao WT, Chen CY, Chen YL, Chen BH, Chen GS, Wang JJ. Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo. Chem Biol Interact. 2009; 180:360-367. (IF: 2.577; 110/255)
  27. Liao WT, Yu CL, Lan CC, Lee CH, Chang CH, Chang LW, You HL, Yu HS. Differential effects of arsenic on cutaneous and systemic immunity: focusing on CD4+ cell apoptosis in patients with arsenic-induced Bowen's disease. Carcinogenesis.2009; 30: 1064-1072. (IF: 5.334; 27/211)
  28. Liao WT, Lin P, Cheng TS, Yu HS, Chang LW. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. Toxicol Appl Pharmacol. 2007; 225: 162-170. (IF: 3.705; 15/88)
  29. You HL, Eng HL, Hsu SF, Chen CM, Ye TC, Liao WT, Huang MY, Baer R, Cheng JT. A PKC-Sp1 signaling pathway induces early differentiation of human keratinocytes through upregulation of TSG101. Cell Signal.2007; 19:1201-1211. (IF: 4.315; 65/184)
  30. Yu HS, Liao WT, Chai CY. Arsenic carcinogenesis in the skin. J Biomed Sci. 2006;13: 657-666. (IF: 2.763; 50/123)
  31. Lee CH, Chen JS, Sun YL, Liao WT, Zheng YW, Chai CZ, Chen GS, Yu HS. Defective beta1-integrins expression in arsenical keratosis and arsenic-treated cultured human keratinocytes. J Cutan Pathol.2006; 33:129-138. (IF: 1.582; 30/63)
  32. Lee CH, Yu CL, Liao WT, Kao YH, Chai CY, Chen GS, Yu HS. Effects and interactions of low doses of arsenic and UVB on keratinocyte apoptosis. Chem Res Toxicol. 2004;17: 1199-1205. (IF: 3.529; 10/59)
  33. Liao WT, Chang KL, Yu CL, Chen GS, Chang LW, Yu HS. Arsenic induces human keratinocyte apoptosis by the FAS/FAS ligand pathway, which correlates with alterations in nuclear factor-kappa B and activator protein-1 activity. J Invest Dermatol. 2004;122: 125-129. (IF: 7.216; 1/63)
  34. Lan CC, Yu HS, Liao WT, Hsu RC, Chung JC, Tsai KB, Chen GS. Clear cell eccrine porocarcinoma with extensive cutaneous metastasis and peripheral lymphocyte dysfunction. Br J Dermatol. 2003;149: 1059-63. (IF: 4.275; 6/63)
  35. Chang KL, Liao WT, Yu CL, Lan CC, Chang LW, Yu HS. Effects of gallium on immune stimulation and apoptosis induction in human peripheral blood mononuclear cells. Toxicol Appl Pharmacol. 2003;193: 209-217. (IF: 3.705; 15/88)
  36. Yu HS, Liao WT, Chang KL, Yu CL, Chen GS. Arsenic induces tumor necrosis factor alpha release and tumor necrosis factor receptor 1 signaling in T helper cell apoptosis. J Invest Dermatol. 2002; 119: 812-819. (IF: 7.216; 1/63)

 

Book:

Yu H-S and Liao W-T (2011) Gallium: Environmental pollution and health effects. In: Nriagu JO (ed.) Encyclopedia of Environmental Health, volume 2, pp. 829–833 Burlington: Elsevier.

 

Journal Editor:

Associate Editor, Gout and Hyperuricemia (Elsevier)

 

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