Hu WP

 

聯絡方式

  • 辦公室: 第一教學大樓N824室
  • 實驗室: 第一教學大樓N840室
  • 電話: (07) 3121101 ext. 2683
  • 傳真: (07) 3125339
  • 電子郵件: wphu@kmu.edu.tw

 

學經歷

  • 政治大學政治系法學士 (1983)
  • 美國北德州大學化學所碩士 (1988)
  • 高雄醫學大學醫學研究所理學博士 (2007) 


主負責授課科目

  • 普通化學
  • 普通化學實驗
  •  細胞組織培養技術
  • 分離技術
  • 細胞生物學


研究興趣

1. 抗癌藥物之生物活性評估

2. 光感藥物 (photosensitizer) 之生物活性評估

a. 抗光老化 (antiphotoaging) 研究

 研究興趣1

b. 光動力治療 (photodynamic therapy)研究

研究興趣2

 

  • 期刊論文

1. G. C. Senadi, C. M. Liao, K. K. Kuo, J. C. Lin, L. S. Chang, J. J. Wang, W. P. Hu ,* “Design, synthesis and antimetastatic evaluation of 1-benzothiazolylphenylbenzotriazoles for photodynamic therapy in oral cancer cells” MedChemComm 2016, in press (通訊作者, SCI, 27/59, IF: 2.495).

2. J. H. Jiang, S. S. K. Boominathan, W. P. Hu, C. Y. Chen, J. K. Vandavasi, Y. T. Lin, J. J. Wang,* “Sequential, One-Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols” Eur. J. Org. Chem. 2016, 2284–2289 (SCI, 14/58, IF: 3.065).

3. Y. J. Chen, C. Y. Tsai, W. P. Hu, L. S. Chang,* “DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins” Toxins (Basel). 2016 Mar 5;8 (SCI, 28/88, IF: 2.938).

4. Y. W. Chou, G. C. Senadi, C. Y. Chen, K. K. Kuo, Y. T. Lin, J. J. Wang, J. H. Lee, Y. C. Wang, W. P. Hu ,* “Design and Synthesis of Pyrrolobenzodiazepine-Gallic Hybrid Agents as p53-Dependent and -Independent Apoptogenic Signaling in Melanoma Cells” European Journal of Medicinal Chemistry 2016, 109, 59-74 (通訊作者, SCI, 11/59, IF: 3.447).

5. C. H. Huang, Y. J. Chen, T.Y. Chao, W. H. Liu, J. J. Changchien, W. P. Hu, L. S. Chang,* “.The Association between p38 MAPK-Mediated TNF-α/TNFR2 Up-Regulation and 2-(4-Aminophenyl)-7-Methoxybenzothiazole-Induced Apoptosis in Human Leukemia U937 Cells” J Cell Physiol. 2016, 231(9), 130-141 (SCI, 15/83, IF: 3.839).

6. W. P. Hu, C. C. Hsu, Y. C. Wang, G. C. Senadi, K. K. Kuo, J. F. JEN and J. J. Wang,* “ Bis(phenylidenebenzeneamine)-1-disulfide Derivatives Induce Autophagy in Melanoma cells Through a Mitochondria-mediated Pathway” Anticancer Research 2015, 35, 6075-6080 (第一作者, SCI, 161/211, IF: 1.826).

7. G. C. Senadi, W. P. Hu, A. M. Garkhedkar, S. S. K. Boominathan, and J. J. Wang,* “Palladium(II)-catalysed regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstituted pyrroles from alkenes via anti-Markovnikov selectivity†”, ChemComm 2015, 51(72), 13795-13798 (SCI, 20/157, IF: 6.834).

8. J. K. Vandavasi, W. P. Hu, G. C. Senadi, H. T. Chen, H. Y. Chen, K. C. Hsieh, and J. J. Wang,* “Aryl l3-Iodane-Mediated 6-exo-trig Cyclization to Synthesize Highly Substituted Chiral Morpholines”, Advanced Synthesis & Catalysis 2015, 357(13) 2788 – 2794 (SCI, 2/70, IF: 5.663).

9. J. K. Vandavasi, W. P. Hu, S. S. K. Boominathan, B. C. Guo, C. T. Hsiao and J. J. Wang,* “Au(I)-catalyzed synthesis of 8-oxabicyclo[3.2.1]oct-2-enes and 9-oxabicyclo[3.3.1]nona-2,6-dienes from enynol via oxonium/Prins-type cyclization†”, ChemComm 2015, 51(62), 12435-12438 (SCI, 20/157, IF: 6.834).

10. J. K. Vandavasi, C. T. Hsiao, W. P. Hu, S. S. K. Boominathan, and J. J. Wang,* “Silver(I)-Catalyzed Tandem Approach to β-Oxo Amides”, Eur. J. Org. Chem. 2015, 3171–3177 (SCI, 13/57, IF: 3.065).

11. G. C. Senadi, W. P. Hu, T. Y. Lu, A. M. Garkhedkar, J. K. Vandavasi, and J. J. Wang,*“I2−TBHP-Catalyzed Oxidative Cross-Coupling of N‑Sulfonyl Hydrazones and Isocyanides to 5‑Aminopyrazoles”, Organic Letters 2015, 17(6), 1521-1524 (SCI, 4/57, IF: 6.364).

12. G. C. Senadi, W. P. Hu, S. S. K. Boominathan, and J. J. Wang,* “Palladium(0)-Catalyzed Single and Double Isonitrile Insertion: A Facile Synthesis of Benzofurans, Indoles, and Isatins”, Chem. Eur. J. 2015, 21, 998 – 1003. (SCI, 22/157, IF: 5.731).

13. C. S. Wu,* H. Y. Kuo, W. P. Hu, J. J. Wang, A. H. Fang and L. Y. Tien, “The ultraviolet A-activated photosensitizer 2-(4-aminophenyl)- 7-methoxybenzothiazole suppresses proliferation and induces apoptosis of keloid fibroblasts: a potential adjunctive therapy for keloids”, Clinical and Experimental Dermatology 2015, 40(1), 63-70. (SCI, 45/62, IF: 1.092).

14. J. K. Vandavasi, W. P. Hu, C. T. Hsiao, G. C. Senadi, and J. J. Wang,* “A new approach for fused isoindolines via hexadehydro-Diels–Alder reaction (HDDA) by Fe(0) catalysis†”, RSC Advances 2014, 4, 57547-57552 (SCI, 33/157, IF: 3.840).

15. J. K. Vandavasi, W. P. Hu, G. C. Senadi, S. S. K. Boominathan, H. Y. Chen,* and J. J. Wang,* “A K2CO3-Mediated Regioselective Synthesis of Indole/Pyrrole-Fused 1,4-Oxazines: An Unexpected Indole-Fused Azlactone Synthesis, Eur. J. Org. Chem. 2014, 28, 6219-6226 (SCI, 13/57, IF: 3.065).

16. Y. K. Chen, G. C. Senadi, C. H. Lee, Y. M. Tsai, Y. R. Chen, W. P. Hu, * Y. W. Chou, K. K. Kuo, and J. J. Wang,* “Mediated Photodynamic Therapy in Melanomas via Mitochondrial Dysfunction” Chemical Research in Toxicology, 2014 , 27(51), 1187-1198 (通訊作者, SCI, 10/59, IF: 3.529). ACS Author Rewards 2015

17. S. S. K Boominathan, W. P. Hu, G. C. Senadi, J J. K. Vandavasi and J. J. Wang,* “A one-pot hypoiodite catalysed oxidative cycloetherification approach to benzoxazoles†” Chem. Commun. 2014, 50(51), 6726-6728 (SCI, 20/157, IF: 6.834).

18. Y. L. Chiou, S. R. Lin, SR, W. P. Hu, L. S. Chang,* “Modulated mechanism of phosphatidylserine on the catalytic activity ofNaja naja atra phospholipase A2 and Notechis scutatus scutatus notexin.” Toxicon, 2014, 15(92), 113-122 (SCI, 115/254, IF: 2.492).

19. S. S. K Boominathan, W. P. Hu, G. C. Senadi and J. J. Wang,* “Silver(I)-Catalyzed Conia-Ene Reaction: Synthesis of 3-Pyrrolines via a 5-endo-dig Cyclization” Advanced Synthesis & Catalysis 2013, 355(18), 3570-3574 (SCI, 2/70, IF: 5.663).

20. C. Y. Chen, W. P. Hu, P. C. Yan, G. C. Senadi, and J. J. Wang,* “ Metal-Free, Acid-Promoted Synthesis of Imidazole Derivatives via a Multicomponent Reaction” Organic Letters 2013, 15(24), 6116-6119 (SCI, 4/57, IF: 6.364).

21. G. C. Senadi, W. P. Hu, S. S. K Boominathan, and J. J. Wang,* “Nickel- or Palladium-Catalyzed Stereoselective Synthesis of Tetrasubstituted Olefinic Indolines-Fused Triazoles: Extension to the Spiroindoline Core” Advanced Synthesis & Catalysis 2013, 355(18), 3679-3693 (SCI, 2/70, IF: 5.663).

22. C. Y. Chen, P. H. Lee, Y. Y. Lin, W. T. Yu, W. P. Hu, * C. C. Hsu, Y. T. Lin, L. S. Chang, C. T. Hsiao, J. J. Wang,* M. I. Chung .*“Synthesis, DNA-binding Abilities and Anticancer Activities of Triazole-Pyrrolo[2,1-c][1,4]benzodiazepines Hybrid Scaffolds” Bioorg. Med. Chem. Lett. 2013, 23, 6854-6859 (通訊作者, SCI, 19/57, IF: 2.420).

23. C.Y. Chen , W. P. Hu, M. C. Liu , P. C. Yan , J. J. Wang,* M. I. Chung .*“Efficient synthesis of quinoxalines with hypervalent iodine as a catalyst” , Tetrahedron 2013, 69, 9735-9741 (SCI, 17/57, IF: 2.641).

24. J. K. Vandavasi, K. K. Kuo, W. P. Hu, H. C. Shen, W. S. Lo, J. J. Wang.* “A convenient method to construct (Z)- oxazines via 6-exo-dig iodocyclization and synthesize of indolin-3-one", Org. Biomol. Chem., 2013, 11, 6520-6525 (SCI, 11/57, IF: 3.562).

25. H. Y. Hsieh, W. C. Lee, G. C. Senadi, W. P. Hu,* J. J. Liang, T. R. Tsai, Y. W. Chou, C. Y. Chen, J. J. Wang.* “Discovery, Synthetic Methodology and Biological Evaluation for Anti-Photoaging Activity of Bicyclic[1,2,3]Triazoles: In Vitro and in Vivo Studies”, J. Med. Chem. 2013, 13, 5422-5435 (通訊作者, SCI, 3/59, IF: 5.447).

26. C. Y. Chen, Y. K. Chen, J. J. Wang, C. C Hsu, F. Y. Tsai, P. J. Sung, H. C. Lin, L. S. Chang, W. P. Hu.* “DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways”, Cell Biol Toxicol 2013, 29, 85–99 (通訊作者, SCI, 38/87, IF: 2.677).

27. P. H. Kao, Y. J. Chen, S. Y. Yang, S. R. Lin, W. P. Hu, L. S. Chang,* “Fusogenicity of Naja naja atra cardiotoxin-like basic protein on sphingomyelin vesicles containing oxidized phosphatidylcholine and cholesterol” Journal of biochemistry. 2013, 153, 523-533 (SCI, 154/289, IF: 2.582).

28. L. C. Hu, J. H. Su, Michael Y. N. Chiang , M. C. Lu , T. L. Hwang , Y. H. Chen , W. P. Hu, N. C. Lin , W. H. Wang , L. S. Fang , Y. H. Kuo ,* P. J. Sung,* “Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis ” Marine Drugs 2013,11, 1999-2012 (SCI, 22/59, IF: 2.853).

29. C. Y. Chen, C. H. Yang, W. P. Hu, J. K. Vandavasi, M.I. Chung, J. J. Wang.* “Synthesis of Fused Triazolo [4,5-d]quinoline/ chromene/ thiochromene Derivatives via Palladium Catalysis Mediated by Tetrabutylammonium Iodide”, RSC Advances, 2013, 3, 2710-2719 (SCI, 33/157, IF: 3.840).

30. C. F. Su, W. P. Hu, J. K. Vandavasi, C. C. Liao, C. Y. Hung, J. J. Wang ,* “ortho-Amide-Directed Oxidation of Internal Aryl Alkynes Mediated by Cerium(IV) Ammonium Nitrate” SYNLETT, 2012, 23, 2132-2136 (SCI, 20/57, IF: 2.419).

31. G.C. Senadi, W. P. Hu, J.S. Hsiao, J.K. Vandavasi, C.Y. Chen, J. J. Wang ,* “Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI(2) and FeCl(3) ” Organic Letters 2012, 14(17):4478-4481 (SCI, 4/57, IF: 6.364).

32. W.C. Lee, H.C. Shen, W. P. Hu, W.S. Lo, Chebrolu Murali, J.K. Vandavasi J. J. Wang ,* “Iodine-Catalyzed, Stereo- and Regioselective Synthesis of 4-Arylidine-4H-benzo[d][1,3]oxazines and their Applications for the Synthesis of Quinazoline 3-Oxides” Advanced Synthesis & Catalysis 2012, 354, 2218-2228 (SCI, 2/70, IF: 5.663).

33. P. H. Kao, S. R. Lin, W. P. Hu, L. S. Chang,* “ Naja naja atra and Naja nigricollis cardiotoxins induce fusion of Escherichia coli and Staphylococcus aureus membrane-mimicking liposomes” Toxicon 2012, 60, 367-377 (SCI,115/254, IF: 2.492).

34. J.K. Vandavasi, W. P. Hu, H. Y. Chen, G. C. Senadi, C. Y. Chen, J. J. Wang ,* “A new approach to 1,4-oxazines and 1,4-oxazepines via base-promoted exo mode cyclization of alkynyl alcohols: mechanism and DFT studies”Organic Letters 2012, 14, 3134-3137 (SCI, 4/57, IF: 6.364).

35. Y. L. Chiou, S. R. Lin, W. P. Hu, L. S. Chang,* “ Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2”J Biosci. 2012, 37, 277-287 (SCI, 24/85, IF: 2.064).

36. J.K. Vandavasi, W. P. Hu, C. Y. Chen , J. J. Wang ,* “Efficient synthesis of unsymmetrical disulfides” Tetrahedron 2011, 67, 8895-8901 (SCI, 17/57, IF: 2.641).

37. L. W. Chen, P. H. Kao, Y. S. Fu, W. P. Hu, L. S. Chang,* “Bactericidal effect of Naja nigricollis toxin is related to its membrane-damaging activity” Peptides 2011, 32, 1755–1763 (SCI, 108/254, IF: 2.618).

38. M. C. Hsieh , W. P. Hu, H. S. Yu , W. C. Wu , L. S. Chang ,Y. H. Kao, J. J. Wang ,* “A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling” Toxicology and Applied Pharmacology 2011, 255, 150–159 (SCI, 13/87, IF: 3.705).

39. W. S. Lo, W. P. Hu, H. P. Lo, C. Y. Chen, C. L. Kao, Vandavasi JK, and J. J. Wang,* “Synthesis of sulfur-sulfur bond formation from thioamides promoted by 2,3-dichloro-5,6-dicyanobenzoquinone” Organic Letters 2010, 12, 5570-5572 (SCI, 4/57, IF: 6.364).

40. W. P. Hu, Y. K. Chen, C. C. Liao, H. S. Yu, Y. M. Tsai, S. M. Huang, F. Y. Tsai, H. C. Shen, L. S. Chang, and J. J. Wang,* “Synthesis, and biological evaluation of 2-(4-Aminophenyl)benzothiazole derivatives as photosensitizing agents”, Bioorg. Med. Chem. 2010, 18, 6197-6207 (第一作者, SCI, 14/57, IF: 2.793).

41. 41. P. J. Sung,* S. H. Wang, M. Y. Chiang, Y. D. Su, Y. C. Chang, W. P. Hu, C. Y. Tai and C. Y. Liu “Discovery of New Chlorinated Briaranes from Junceella fragilis”, Bull. Chem. Soc. Jpn. 2009, 82, 1426-1432 (SCI).

42. C. H. Lee, W. P. Hu, C. H. Hong, H.S. Yu, W. T. Liao, C.Y. Chen, B. H. Chen, G. S. Chen, J. J. Wang,* “Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo”, Chemico-Biological Interactions 2009, 180, 360-367 (SCI).

43. T. L. Hwang, Y. D. Su, W. P. Hu, L. F. Chuang, and P. J. Sung “Rumphellolide H, A New Natural Caryophyllane from the Gorgonian Rumphella Antipathies”, Heterocycles 2009, 78, 1563-1567 (SCI).

44. W. P. Hu, J. J. Liang, C. L. Kao, Y. C. Chen, C. Y. Chen, F. Y. Tsai, M. J. Wu, L. S. Chang, Y. L. Chen and J. J. Wang “Synthesis and antitumor activity of novel enediyne -linked pyrrolo[2,1-c] [1,4]benzodiazepine hybrids”, Bioorg. Med. Chem. 2009, 17, 1172-1180 (第一作者, SCI).

45. T. L Hwang, M. R. Lin, W. T. Tsai, H. C. Yeh, W. P. Hu, J. H. Sheu and P. J. Sung “New Polyoxygenated Briaranes from Octocorals Briareum Excavatum and Ellisella Robusta”, Bull. Chem. Soc. Jpn. 2008, 81, 1638-1646 (SCI).

46. W. P. Hu, F. Y. Tsai, H. S. Yu, P. J. Sung, Y. K. Shen, L. S. Chang and J. J. Wang “Induction of Apoptosis by DC-81-Indole Conjugate Agent Through NF-кB and JNK/AP-1 Pathway”, Chemical Research in Toxicology 2008, 21, 1330-1336 (SCI)

47. A. F. Ahmed, S. H. Tai, Z. H. Wen, J. H. Su, Y. C. Wu, W. P Hu and J. H. Sheu “A C-3 Methylated Isocembranoid and 10-Oxocembranoids from a Formosan Soft Coral Sinularia grandilobata”, J. Nat. Prod. 2008, 71, 946-951 (SCI).

48. W. P Hu, H. S. Yu, Y. M. Tsai, Y. R. Chen, Y. K. Chen, L. S. Chang and J. J. Wang “Synthesis and biological evaluation of thiobenzanilides as anticancer agents”, Bioorganic & Medicinal Chemistry. 2008, 16, 5295-5302 (SCI).

49. A. F. Ahmed, Z. H. Wen, J. H. Su, Y. T. Hsieh, Y. C. Wu, W. P. Hu,∥and J. H. Sheu “Oxygenated Cembranoids from a Formosan Soft Coral Sinularia gibberosa”, J. Nat. Prod. 2008, 71, 179-185 (SCI).

50. P. J. Sung, M. R. Lin,Y. D. Su, M. Y. Chiang, W. P. Hu, J. H. Su, M. C. Cheng, T. L. Hwang and J. H. Sheu “New briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae)”, Tetrahedron 2008, 64, 2596-2604 (SCI).

51. P. J. Sung, L. F. Chuang, and W. P. Hu “Rumphellatins B and C, Two New Caryophyllane-Type Hemiketal Norsesquiterpenoids from the Formosan Gorgonian Coral Rumphella antipathies. Bull. Chem. Soc. Jpn. 2007, 80, 2395-2399 (SCI).

52. W. P. Hu, H. S. Yu, P. J. Sung, F. Y. Tsai, Y. K. Shen L. S. Chang and J. J. Wang “DC-81-Indole Conjugate Agent Induces Mitochondria Mediated Apoptosis in Human Melanoma A375 Cells”, Chemical Research in Toxicology 2007, 20, 905-912 (SCI).

53. P. J. Sung, L. F. Chuang, J. Kuo, T.Y. Fan and W. P. Hu ‘Rumphellatin A, the first chloride-containing caryophyllane-type norsesquiterpenoid from Rumphella antipathies”, Tetrahedron Letters 2007, 48, 3987-3989 (SCI).

54. W. P. Hu, J. J. Wang, C. L. Yu, C. C. E. Lan, G. S. Chen and H. S. Yu “Helium-Neon Laser Irradiation Stimulates Cell Proliferation Through Photostimulatory Effects in Mitochondria”, J Invest Dermatol. 2007, 127, 2048-2057 (SCI)

55. P. J. Sung, Y. P. Chen, Y. M. Su, T. L. Hwang, W. P. Hu, T. Y. Fan, and W. H. Wang “Fragilide B, a Novel Briarane-type Diterpenoid with an S-cis Diene Moiety”, Bull. Chem. Soc. Jpn. 2007, 80, 1205-1207 (SCI).

56. J. H. Su, F. Y. Lin, H. C. Huang, C. F. Dai, Y. C. Wu, W. P. Hu, C. H. Hsu and J. H. Sheu “Novel Steroids from the Soft Coral Nephthea Chabrolii”, Tetrahedron 2007, 63, 703-707 (SCI).

57. W. C. Chen, L. F. Chuang, J. H. Sheu, W. P. Hu, Y. P. Chen, M. R. Lin, L. S. Fang, T. Y. Fan, J.J. Li, P. J. Sung “Gorgosterol, a Cyclopropylsteroid from the Octocoral Alcyonium sp”, Platax 2006, 3, 9–16. (國立海洋生物博物館學術館刊).

58. Y. P. Chen, S. L. Wu, J. H. Su, M. R. Lin, W. P. Hu, T. L. Hwang, J. H. Sheu, T. Y. Fan, L. S. Fang and P. J. Sung “Briaexcavatins G and H, Two New Briaranes from the Octocoral Briareum excavatum”, Bull. Chem. Soc. Jpn. 2006, 79, 1900-1905 (SCI).

59. S. P. Chen, A. F. Ahmed, C. F. Dai, C. K. Lu, W. P. Hu, J. J. Wang and J. H. Sheua “Sinugibberosides A–E, New Terpenoids with Cyclic Peroxyhemiketal from the Soft Coral Sinularia Gibberosa”, Tetrahedron 2006, 62, 6802-6807 (SCI).

60. W. C. Chen, J. H. Sheu, L. S.Fang, W. P. Hu, P. J. Sung “ 3,7,12-Triacetoxy-5- cholanic Acid, a Steroid from the Formosan Soft Coral Alcyonium sp”, Nat. Prod. Res. 2006, 20, 748-753 (SCI).

61. P. J. Sung, Y. P. Chen, T.L. Hwang, W. P. Hu, L. S. Fang, , Y. C. Wu, , J.J. Li, J. H. Sheu “Briaexcavatins C-F, Four New Briarane-related Diterpenoids from the Formosan Octocoral Briareum Excavatum (Briareidae) ”, Tetrahedron 2006, 62, 5686-5691 (SCI).

62. P. J. Sung, L. S. Fang, Y. P. Chen, W. C. Chen, W. P. Hu, C. L. Ho, S. C. Yu “5-Steroids from the Gorgonian Coral Junceella fragilis (Ellisellidae)”, Biochem. Syst. Ecol. 2006, 34, 64 -70 (SCI).

63. J. J Wang, Y. K. Shen, W. P. Hu, M. C. Hsieh, F. L. Lin, M. K. Hsu, and M.H. Hsua “Design, Synthesis, and Biological Evaluation of Pyrrolo[2,1-c] [1,4]benzodiazepine and Indole Conjugates as Anticancer Agents”, J Medicinal Chemistry 2006, 49, 1442-1449 (SCI).

64. P. J. Sung, C.H. Chao, Y.P. Chen, J. H. Su, W. P. Hu, J. H. Sheu “Briaexcavatins A and B, Novel Briaranes from the Octocoral Briareum excavatum”, Tetrahedron Letters 2006, 47, 167-170 (SCI).

65. P. J. Sung, W. P. Hu, L. S. Fang, T. Y. Fan, J. J. Wang “Briarenol A, a New Diterpenoid from a Gorgonian Briareum SP. (Briareiae)”, Nat. Prod. Res. 2005, 19, 689–694 (SCI).

66. P. J. Sung, W. P. Hu, S. L. Wu, T. Y. Fan, J. H. Su, L. S. Fang, J. J. Wang, and J. H. Sheu “Briaexcavatolides X-Z, Three New Briarane-related Derivatives from the Gorgonian Coral Briareum Excavatum”, Tetrahedron 2004, 60, 8975~8979 (SCI).

67. W. P. Hu, P. C. Tsai, M. K. Hsu and J. J. Wang, “Novel Borane Reduction of Ether-Protected Aromatic Lactams”, J. Org. Chem. 2004, 69, 3983~3985 (SCI).

68. W. P. Hu, J. J. Wang, S. M. Huang and H. S. Yu, “Involvement of Cytotoxicity and Variation of the Mitochondrial Membrane Potential Induced by Hybrid Agent”, Drug Development Res. 2004, 61, 1~5 (SCI).

69. J. H. Sheu, L. F. Huang, S. P. Chen, Y. L. Yang, P. J. Sung, G. H. Wang, J. H. Su, C. H. Chao, W. P. Hu and J. J. Wang, “Hippuristerones E-I, New Polyoxygenated Steroids from the Gorgonian Coral Isis hippuris”, J. Nat. Prod. 2003, 66, 917~921 (SCI).

70. W. P. Hu, H. S. Yu, Y. C. Chen and J. J. Wang, “Biological Evaluuation an Antibiotic DC-81-Indole Conjugate Agent in Human Melanoma Cell”, The Kaohsiung Journal of Medical Sciences, 2003, 19, 6~12 (SCI).

71. W. P. Hu, H. S. Yu, M. C. Hsieh, Y. C. Chen and J. J. Wang, “Evaluation of DNA-Binding Ability of Antibiotic DC-81-Indole Conjugates by Restriction Endonuclease BamHI and Molecular Modeling Studies”, Chin. Pharm. J. 2002, 54, No. 6, 465~470.

72. W. P. Hu, J. J. Wang, F. L. Lin, Y. C. Lin, S. R. Lin and M.H. Hsu, “An Efficient Synthesis of Pyrrolo[2,1-c]- [1,4]benzodiazepine. Synthesis of the Antibiotic DC-81”, J. Org. Chem. 2001, 66, 2881~2883 (SCI).

73. W. P. Hu, J, J. Wang and P. C. Tsai, “Novel Examples of 3-Aza-Grob Fragmentation”, J. Org. Chem. 2000, 65, 4208~4209 (SCI).

74. L. S. Chang, S. J. Lin, J. J. Wang, W. P. Hu, B. N. Wu and H. B. Huang, “Structure-Function Studies on Taiwan Cobra Long Neurotoxin Homolog”, Biochimica et Biophysica Acta. 2000, 1480, 293~301(SCI).

75. J. J. Wang and W. P. Hu, “Novel 2-Aza-Grob Fragmentation in Hydride Reduction of Ether-Protected Aromatic Lactams”, J. Org. Chem. 1999, 64, 5725~5727(SCI).

76. J. J. Wang, W. P. Hu, H. W. Chung, L. F. Wang and M. H. Hsu, “A New and Novel Amide Bond Cleavage of N-methoxymethylpyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones by Hydrde Reduction via 3-Aza-Grob Fragementation”, Tetrahedron 1998, 54, 13149~13154 (SCI).

77. C.H. Chang, Y.M. Sheu, W. P. Hu and L.F. Wang. "Synthesis and Properties of Copolymers from 2-Hydroxyethyl Methacrylate-Llinked Non-Steroidal Antiin Flammatory Agents with Methacrylic Acid", J. Polym. Sci., Polym. Chem 1998, 36, 1481-1490 (SCI).

78. W. P. Hu, L.F. Wang and K.W. Leong, "Synthesis and Characterization of Methacylic Derivatives as Drug Carriers", Drug Development and Industrial Pharmay 1997 , 23(7), 671-678 (SCI).

79. C. N. Lin, P. L. Huang, C. M. Lu, R. R. Wu, W. P. Hu, and J. J. Wang, “Polygonapholine, an Alkaloid with a Novel Skeleton, Isolated from Polygonatum Alte-lobatum”, Tetrahedron 1997, 53, 2025~2028(SCI).

80. S.P. Wang, W. P. Hu and M. Schwartz, "Raman Bandshape of the Degenerate ν4 Vibration and Parallel Rotational Diffusion in CD3I", Molecular Physics 1989 , 68(5), 1125-1129 (SCI).

81. W. P. Hu, A.A. Rodriguez and M. Schwartz ,. "Solvent Dependence of Peak Frequencies an Bandwidths of the ν4 Vibration of the Series CH3MCL3, M=C, Si, Ge, Sn", Spectrochimica Acta 1989 , 45A(9), 929-932 (SCI).

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