邱建智教授 (Chien-Chih Chiu)

S 2236492

 

聯絡方式:

 

學經歷:

  • 中山大學生物系理學士 (1996)
  • 中山大學生物科學系碩士 (1998)
  • 臺灣師範大學生命科學系理學博士 (2004)
  • 臺灣師範大學生命科學系 博士後研究員 (2004-2005)
  • 高雄師範大學生物科技學系 兼任助理教授 (2006)
  • 高雄醫學大學生物科技學系 助理教授 (2005-2011)
  • 高雄醫學大學附設中和醫院 轉譯醫學研究中心 兼任副研究員 (2014)
  • 高雄醫學大學生物科技學系 副教授 (2011.08 - 2014.08)
  • 高雄醫學大學生物科技學系 教授 (2014.09 - Presen)
  • 高雄醫學大學醫學研究所 合聘教授 (2016.08 - Present)
  • 高雄醫學大學附設中和醫院 臨床醫學研究中心 兼任研究員 (2017.08 - Present)
  • 中山大學生物科學系 合聘教授 ( 2016.08- Present) 


主負責授課科目：

  • 基因體學與蛋白質體學
  • 腫瘤生物學
  • 書報討論 
  • 專題研究 (大學三年級與四年級)
  • 實驗室實習 (大學部二年級)

 

講義下載：

  • 大學部課程

普通生物學
普通生物學實驗
服務學習
電腦生物
分子生物學
自由基生物學
基因體及蛋白質體學
腫瘤生物學

  • 研究所課程

腫瘤生物學特論
細胞生物學特論
生命科學特論

 

 研究興趣:

  • 抗癌藥物篩選與機制探討
  • mRNA輸出調節與腫瘤相關基因表現機制
  • 斑馬魚模型在藥物篩選的應用

 ＠＠　招募實驗室生力軍！　歡迎積極有耐心、願意學習的同學加入我們！（不限科系、大一生也很歡迎）

 

 

期刊論文: (連結科技部) 

 Publication since 2013

 1.    Sheng-Kai Hsu†, Chien-Chih Chiu†, Hans-Uwe Dahms, Chon-Kit Chou, Chih-Mei Cheng, Wen-Tsan Chang, Kai-Chun Cheng, Hui-Min David Wang and I-Ling Lin*. Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells. Int. J. Mol. Sci. 2019 Accepted. †Equal contribution.

2.   Han-Lin Chou, Yi-Hsiung Lin, Wangta Liu, Chang-Yi Wu, Ruei-Nian Li, Hurng-Wern Huang, Chi-Hsien Chou, Shean-Jaw Chiou, Chien-Chih Chiu*. Combination therapy of chloroquine and C2-ceramide enhanced cytotoxicity in Lung cancer H460 and H1299 cells. Cancers. 2019. 11(3):370.

3.     Yi-Chen Wang, Xing-Yu Haung, Chien-Chih Chiu, Meng-Yi Lin, Wen-Hung Lin, Wen-Tsan Chang, Chung-Chih Tseng, Hui-Min David Wang. Inhibitions of melanogenesis via Phyllanthus emblica fruit extract powder in B16F10 cells. Food Bioscience. 2019. 28:177-182.

4.     Chon-Kit Chou, Hurng-Wern Huang, Chun-Feng Yang, Hans-Uwe Dahms, Shih-Shin Liang, Tsu-Nai Wang, Po-Lin Kuo, Edward Hsi, Eing-Mei Tsai*, Chien-Chih Chiu*. Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes Environ Toxicol. 2019 34(4):401-414.

5.     CM Chien, JC Yang, PH Wu, CY Wu, GY Chen, YC Wu, CK Chou, CH Tseng, YL Chen*, Li-Fang Wang*, Chien-Chih Chiu*. Phytochemical Naphtho[1,2-b] furan-4,5-dione Induced Topoisomerase II-mediated DNA Damage Response in Human Non-small-Cell Lung Cancer. Phytomedicine. 2019, 54: 109-119 

6.    Feng-Chi Hsieh, Chun-Tzu Hung, Kai-Chun Cheng, Chang-Yi Wu, Yen-Chun Chen, and Yu-Jen Wu, Wangta Liu*, Chien-Chih Chiu*. Protective effects of Lycium barbarum extracts on UVB-induced damage in human retinal pigment epithelial cells accompanied by attenuating ROS and DNA damage. Oxid Med Cell Longev. 2018. Article ID 4814928

7.      YC. Chang, Y Fong, EM Tsai, YG Chang, HL Chou, CY Wu, YN Teng, TC Liu, SS Yuan and Chien-Chih Chiu*. Exogenous C8-ceramide induces apoptosis by over-production of ROS and the switch of superoxide dismutases SOD1 to SOD2 in human lung cancer cells. Int. J. Mol. Sci. 2018. 19(10), 3010.

8.    Chon-Kit Chou, Wangta Liu, Yu-Jie Hong, Hans-Uwe Dahms, Chen-Hao Chiu, Wen-Tsan Chang, Ching-Ming Chien, Chia-Hung Yen, Yuan-Bin Cheng*, Chien-Chih Chiu*. Ethyl acetate extract of Scindapsus cf. hederaceus exerts the inhibitory bioactivity on human non-small cell lung cancer cells through modulating ER stress. Int. J. Mol. Sci. 2018, 19.7: 1832.

9.      YH CHIU, SH HSU, HW HSU, KC HUANG, W LIU, CY WU, WP HUANG, JEFF YF CHEN, BH CHEN and Chien-Chih Chiu*. Human lung cancer cells can be sensitized to camptothecin by modulating autophagy. Int J Oncol. 2018, 53.5: 1967-1979.

10.   Chon-Kit Chou, Ya-Ting Yang, Ho-Chun Yang, Shih-Shin Liang, Tsu-Nai Wang, Po-Lin Kuo, Hui-Min David Wang, Eing-Mei Tsai*, Chien-Chih Chiu*. The impact of Bis(2-ethylhexyl) phthalate (DEHP) on cancer progression. Archivum Immunologiae et Therapiae Experimentalis. 2017 66.3: 183-197.

11.     Yi-Chun Song, Bao-Jueng Wu, Chien-Chih Chiu, Chun-Lin Chen, Jun-Qing Zhou, Shuo-Rong Liang, Chang-Yih Duh, Ping-Jyun Sung, Zhi-Hong Wen, Chang-Yi Wu*. Coral-Derived Natural Marine Compound GB9 Impairs Vascular Development in Zebrafish. International Journal of Molecular Sciences. 2017 Aug 3;18(8)

12.     Shyng-shiou Yuan, Chie-Hong Wang, Po-Jen Wang, Ya-Ching Hsieh, Steven Lo, Yi-Chen Lee, Yueh-Chiu Chen, Chun-Hao Tsai, Wen-Chin Chiu, Stephen Hu, Chun-Wun Lu, Yi-Fang Yang, Chien-Chih Chiu, Fu Ou-Yang, Yun-Ming Wang, and Ming-Feng Ho. Resistin facilitates breast cancer progression via TLR4 mediated induction of mesenchymal phenotypes and stemness properties. Oncogene. 2017 Oct 9. doi: 10.1038/onc.2017.357. [Epub ahead of print]

13.     WT Chang, W Liu, YH Chiu, BH Chen, SC Chuang, YC Chen, YT Hsu, MJ Lu, SJ Chiou, CK Chou and Chien-Chih Chiu*. A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression. Molecules, 2017, 22,854. 

14.     Chang WT, Fong Y, Chuang SC, Chou CK, Chou HL, Yang CF, Tseng CH, Chen YL, Chien-Chih Chiu*. 9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno [1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis. Anticancer Agents Med Chem.2017;17(5):692-700.

15.     Chang Wen-Ni, Chi Wan-Yu, Kao Tseng-Ting, Tsai Jen-Ning, Liu Wangta, Liang Shih-Shin, Chiu Chien-Chih, Chen Bing-Hung and Fu Tzu-Fun. The Transgenic Zebrafish Display Fluorescence Reflecting the Expressional Dynamics of Dihydrofolate Reductase. Zebrafish. 2017 Jun;14(3):223-235.

16.     Wen-Tsan Chang, Wangta Liu, Yi-Han Chiu, Bing-Hung Chen, Shih-Chang Chuang , Yen-Chun Chen, Yun-Tzh Hsu, Mei-Jei Lu, Shean-Jaw Chiou, Chon-Kit Chou and Chien-Chih Chiu*. A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression. Molecules. 2017 May 21;22(5)

17.     Chon-Kit Chou, Chin-Ju Tang, Han-Lin Chou, Chun-Yen Liu, Ming-Chong Ng, Yu-Ting Chang, Shyng-Shiou F. Yuan, Eing-Mei Tsai, Chien-Chih Chiu*. The Potential Role of Krüppel-Like Zinc Finger Protein Glis3 in Genetic Diseases and Cancers. Arch Immunol Ther Exp (Warsz). 2017 May 18

18.     Hsueh-Wei Chang, Wen-DerWang, Chien-Chih Chiu, Chiou-Hua Chen, Yi-Shan Wang, Zih-Ying Chen, Wangta Liu, Ming-Hong Tai, Zhi-Hong Wen and Chang-Yi Wu*. Ftr82 Is Critical for Vascular Patterning during Zebrafish Development. Int J Mol Sci. 2017 Jan 13;18(1).

19.     Ting-Yun Wu, Yi-Shan Wang, Yi-Chun Song, Zih-Ying Chen, Yi-Ting Chen, Chien-Chih Chiu, Chang-Yi Wu*. Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development. Scientific Reports. 2017 May 12;7(1):1852.

20.     Fong Y, Wu CY, Chang KF, Chen BH, Chou WJ, Tseng CH, Chen YC, Wang HD, Chen YL, Chien-Chih Chiu*. Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells. Cancer Cell Int. 2017 Mar 7;17:37.

21.     Huang PC, Chien-Chih Chiu, Chang HW, Wang YS, Hsiu HH, Song YC, Wen ZH, Tai MH and Wu CY*. PrdxI encode peroxiredoxin is important for vascular development in zebrafish. FEBS Lett. 2017 Mar;591(6):889-902.

22.     Chon-Kit Chou, Yu-Ting Chang, Michal Korinek, Yei-Tsung Chen, Ya-Ting Yang, Steve Leu, I-Ling Lin, Chin-Ju Tang, Chien-Chih Chiu*.The regulations of deubiquitinase USP15 and its pathophysiological mechanisms in diseases. Int J Mol Sci. 2017 Feb 24;18(3)

23.     Yuli C. Chang, Chien-Chih Chiu, Chung-Yee Yuo, Wen-Ling Chan, Ya-Sian Chang, Wen-Hsin Chang, Shou-Mei Wu, Han-Lin Chou, Ta-Chi Liu, Chi-Yu Lu, Wen-Kuang Yang, Jan-Gowth Chang*. An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation. Oncotarget. 2016. doi: 10.18632/oncotarget.13433. [Epub ahead of print]

24.     Jen-Jie Lin, Robert Y. L. Wang, Jiing-Chuan Chen, Chien-Chih Chiu, Ming-Hui Liao* and Yu-Jen Wu*. Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction. Int. J. Mol. Sci. 2016. 17(11), 1787.

25.     Jeng HA, Pan CH, Chao MR, Chien-Chih Chiu, Zhou G, Chou CK, Lin WY. Sperm quality and DNA integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons. Int J Occup Med Environ Health. 2016 Nov 18;29(6):915-926.

26.     Chou HL, Fong Y, Lin HH, Tsai EM, Chen YF, Chang WT, Wu CY, Wang HM, Huang HW and Chien-Chih Chiu* “An acetamide derivative as a camptothecin sensitizer for human non-small cell lung cancer cells through increased oxidative stress and JNK activation". Oxid Med Cell Longev. 2016. Article ID 9128102.

27.     Fong Y, Tang CC, Hu HT, Fang HY, Wu CY, Yuan SS, Wang HM, Chen YC, Teng YN and Chien-Chih Chiu*. The inhibitory effect of trans-Ferulic acid on proliferation and migration of human lung cancer cells through modulating endogenous ROS and beta-catenin activity. Chinese Medicine, 2016 11:45. eCollection 2016.

28.     Li PH, Chiu YP, Shih CC, Wen ZH, Ibeto LK, Huang SH, Chien-Chih Chiu, Ma DL, Leung CH, Chang YN, Wang HM. Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis. Oxid Med Cell Longev. 2016:2853543.

29.     Chiou SJ, Wang CC, Tseng YS, Lee YJ, Chen SC, Chou CH, Chuang LY, Hong YR, Lu CY, Chien-Chih Chiu, Chignard M. A novel role for β2-microglobulin: a precursor of antibacterial chemokine in respiratory epithelial cells. Sci Rep. 2016 Aug 9;6:31035. 

30.     Liang SS, Wang TN, Chien-Chih Chiu, Kuo PL, Huang MF, Liu MC, Tsai EM. (2016, Feb). Reductive amination-assisted quantitation of tamoxifen and its metabolites by liquid phase chromatography tandem mass spectrometry. Journal of Chromatography A, 1434:64-9.

31.     Hsieh TH, Hsu CY, Tsai CF, Chien-Chih Chiu, Liang SS, Wang TN, Kuo PL, Long CY, Tsai EM. (2016, Jan). A novel cell-penetrating peptide suppresses breast tumorigenesis by inhibiting β-catenin/LEF-1 signaling. Sci Rep, 6:19156.

32.     Liu YS, Cheng RY, Lo YL, Hsu C, Chen SH, Chien-Chih Chiu*, Wang LF*. (*Corresponding authors) (2016, Jan). Distinct CPT-induced deaths in lung cancer cells caused by clathrin-mediated internalization of CP micelles. Nanoscale, 8(6):3510-22.

33.     Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Kung-Kai Kuo, Hua-Lin Wu, Chien-Chih Chiu, Eing-Mei Tsai*, and Po-Lin Kuo* (2015, Dec). Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma. Journal of Agricultural and Food Chemistry, 63(48):10388-98.

34.     Chien-Chih Chiu*, Kuo-Feng Chang, Bing-Hung Chen, Han-Lin Chou, Chih-Hua Tseng, Yao Fong, Tzu-Fun Fu, Hsueh-Wei Chang, Chang-Yi Wu, Eing-Mei Tsai, Shinne-Ren Lin and Yeh-Long Chen* (*Corresponding authors) (2015, Dec). BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model. BMC Cancer, 15:962.

35.     Chih-Hua Tseng, You-Ren Chen, Cherng-Chyi Tzeng, Wangta Liu, Chon-Kit Chou, Chien-Chih Chiu*, Yeh-Long Chen* (*Corresponding authors) (2015, Nov). Discovery of Indeno[1,2-b]quinoxaline Derivatives as Potential Anticancer Agents. European Journal of Medicinal Chemistry.

36.     Chun-Yen Liu, Pei-Tsen Wu, Chun-Li Su, Jing-Ping Wang, Chien-Chih Chiu, Po-Wei Fan, Ching-Fa Yao, Chang-Hung Hsieh, Kang Fang (2015, Nov). An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions. Apoptosis, 20(11): 1471-1482.

37.     Hung JH, Chen CY, Omar HA, Huang KY, Tsao CC, Chien-Chih Chiu, Chen YL, Chen PH, Teng YN. (2015, Sep). Reactive oxygen species mediate Terbufos-induced apoptosis in mouse testicular cell lines via the modulation of cell cycle and proapoptotic proteins.. Environmental Toxicology.

38.     Kai-Chun Cheng, Chun-Tzu Hung, Kuo-Jen Chen, Wen-Chuan Wu, Jau-Ling Suen, Cheng-Hsien Chang, Chi-Yu Lu, Chih-Hua Tseng, Yeh-Long Chen, Chien-Chih Chiu* (2015, Aug). Quinoline-Based Compound BPIQ Exerts Anti-Proliferative Effects on Human Retinoblastoma Cells via Modulating Intracellular Reactive Oxygen Species. Arch Immunol Ther Exp (Warsz). 2015 Apr;64(2):139-47

39.     Lo, Y. L., Lo, P. C., Chien-Chih Chiu, & Wang, L. F. (2015, Aug). Folic Acid Linked Chondroitin Sulfate-Polyethyleneimine Copolymer Based Gene Delivery System. Journal of Biomedical Nanotechnology, 11(8):1385-400.

40.     Shing-Yi Sean Wu, Hui-Min David Wang, Yi-Shan Wen, Wangta Liu, Pin-Hui Li, Chien-Chih Chiu, Pei-Chin Chen, Chiung-Yao Huang Jyh-Horng Sheu, Zhi-Hong Wen. (2015, Aug). 4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo.. International Journal of Molecular Sciences, 16(9):20240-57.

41.     Chon-Kit Chou, Chang-Yi Wu, Jeff Yi-Fu Chen, Ming‐Chong Ng, Hui-Min David Wang, Jen-Hao Chen, Shyng-Shiou F Yuan, Eing-Mei Tsai, Jan-Gowth Chang*, Chien-Chih Chiu* (2015, Jul). BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9. International Journal of Molecular Sciences, 16(7):15104-17.

42.     Wu, Pei-Fang; Chien-Chih Chiu; Chen, Chung-Yi. Wang, Hui-Min. (2015, Jul). 7-Hydroxydehydronuciferine induces human melanoma death via triggering autophagy and apoptosis. Experimental Dermatology.

43.     Lee, C. C., Chen, Y. T., Chien-Chih Chiu, Liao, W. T., Liu, Y. C., & Wang, H. M. D. (2015, Apr). Polygonum cuspidatum extracts as bioactive antioxidaion, antityrosinase, immune stimulation and anticancer agents. Journal of Bioscience and Bioengineering, 119(4):464-9.

44.     Chih-Hua Tseng, Cherng-Chyi Tzeng, Chien-Chih Chiu, Chih-Yao Hsu, Chon-Kit Chou, Yeh-Long Chen*. Discovery of 2-[2-(5-nitrofuran-2-yl)vinyl]quinoline derivatives as a novel type of antimetastatic agents. Bioorganic & Medicinal Chemistry. 2015. Jan 1;23(1):141-8

45.     Chao-Neng Tseng, Yi-Ren Hong, Hsueh-Wei Chang, Tsai-Jung Yu, Ting-Wei Hung, Ming-Feng Hou, Shyng-Shiou F. Yuan , Chung-Lung Cho, Chien-Tsung Liu, Chien-Chih Chiu and Chih-Jen Huang. Brefeldin A Reduces Anchorage-Independent Survival, Cancer Stem Cell Potential and Migration of MDA-MB-231 Human Breast Cancer Cells. Molecules 2014. Oct 29;19(11):17464-77 IF: 2.095

46.     Chih-Chen Lee, Yen-Ting Chen, Chien-Chih Chiu, Su-Shin Lee, Wei-Ting Liao, Kuo-Chuan Huang, Kuo-Chen Cheng *, Hui-Min Wang *. Polygonum cuspidatum Bioactive Extracts from Supercritical Carbon Dioxide Extraction for Antioxidants, Skin Whitening Actors, Anti-inflammation Agents and Cancer Inhibitors. Journal of Bioscience and Bioengineering 2014  IF: 1.869

47.     Bao-Jueng Wu#, Chien-Chih Chiu#, Chun-Lin Chen, Wen-Der Wang, Jia-Hong Wang, Zhi-Hong Wen, Wangta Liu, and Chang-Yi Wu. Nnuclear receptor subfamily 2 group F member 1A (Nr2f1a) is required for vascular development in zebrafish. PLoS ONE. 2014 9(8): e105939. #First author, contributed equally.

48.     Yung-Chieh Tsai, Yen-Ni Teng, Jui-Hsiang Hung, Chien-Hsing Wu, Yu-Ting Kuo, Pao-Lin Kuo, Chien-Chih Chiu, Bin Huang*. The leucine rich domain stabilizes LRWD1 in spermatogenic cells. Adv Med Sci,59(2). 266-72, IF: 2.736

49.     Yao Fong, Ying-Chieh Lin, Chang-Yi Wu, Hui-Min David Wang, Li-Li Lin, Han Lin Chou, Yen-Ni Teng, Shyng-Shiou F Yuan, and Chien-Chih Chiu*. The anti-proliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3A axis. The Scientific World Journal. 2014. Article ID 937051. IF: 1.730

50.     Chih-Hua Tseng, Cherng-Chyi Tzeng, Chien-Chih Chiu, Chiao-Li Yang, Pei-Jung Lu, Chon-Kit Chou, Chun-Yen Liue and Yeh-Long Chen. Antiproliferative Evaluation of 9-Methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinoline-11-one Derivatives. Part 4. MedChemComm. Med. Chem. Commun., 2014,5, 937-948. IF: 2.626

51.     Pei-Chien Tsai, Chiao-Lun Chu, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Lin. Cardiotoxin III suppresses hepatocyte growth factor-stimulated migration and invasion of MDA-MB-231 cells. Cell Biochemistry and Function 06/2014; 32(6):485-95. IF: 2.134

52.     Wen-Tsan Chang, Hsiao-Ling Cheng, Bau-Shan Hsieh, Chien-Chih Chiu, King-Teh Lee and Kee-Lung Chang. Progesterone Increases Apoptosis and Inversely Decreases Autophagy on Human Hepatoma HA22T/VGH Cells Treated with Epirubicin, 2014 The Scientific World Journal.  Article ID 567148 IF: 1.730

53.     Yu-Ting Kao, Wei-Chi Hsu, Huei-Ting Hu, Shih-Hsien Hsu, Chang-Shen Lin, Chien-Chih Chiu, Chi-Yu Lu, Tzyh-Chyuan Hour, Yeong-Shiau Pu, A-Mei Huang. Involvement of p38 mitogen-activated protein kinase in acquired gemcitabine-resistant human urothelial carcinoma sublines. The Kaohsiung Journal of Medical Sciences 01/2014; DOI: 10.1016/j.kjms.2014.03.004 IF: 0.805

54.     Liu, Yu-Sheng; Chiu, Chien-Chih; Chen, Hsuan-Ying; Chen, Su-Hwei; Wang, Li-Fang. Preparing Chondroitin Sulfate-g-Poly(ε-Caprolactone) Copolymers as a CD44-Targeted Vehicle for Enhanced Intracellular Uptake. Molecular Pharmaceutics. Manuscript ID: mp-2013-00607h. 2014.  [Epub ahead of print]

55.     Complex molecular features of gemcitabine-resistant human urothelial carcinoma sublines KJMS-D-13-00197. The Kaohsiung Journal of Medical Sciences. 2014. In press

56.     I-Ling Lin, Han-Lin Chou, Jin-Ching Lee, Feng-Wei Chen, Yao Fong, Wei-Chiao Chang, H.-W. Huang, Chang-Yi Wu, Wen-Tsan Chang, Chien-Chih Chiu*. The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis. “Cancer cell international ”. 2014 Jan. 14:1.

57.     Chao-Neng Tseng, Chung-Lung Cho, Tzan-Wen Chen, Chien-Chih Chiu, Hsueh-Wei Chang, Fang-Rong Chang, Yung-Fu Chang. Brefeldin A inhibits Cancer Stem Cell Properties in Human Lung Cancer Cells. Current Signal Transduction Therapy. 2013. Aug 113-118 (6).

58.     Tsai JR, Chong IW, Chen YH, Hwang JJ, Yin WH, Chen HL, Chou SH, Chien-Chih Chiu, Liu PL. Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells. Archives of pharmacal research, 1-10. 2013. [Epub ahead of print] PMID: 23943503 Aug 14.

59.     Jing-Ping Wang, Kai-Han Lin, Chun-Yen Liu, Ya-Chu Yu, Chien-Chih Chiu, Chun-Li Su, Kwun-Min Chen, Kang Fang. Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53" Toxicology and Applied Pharmacology. 2013. 273(1):110-120. PMID: 23954467 Nov 15;273(1):110-20 (Epub 2013 Aug 15)

60.     Pei-Chien Tsai, Chiao-Lun Chu, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Lin. Inhibition of Src activation with Cardiotoxin III blocks migration and invasion of MDA-MB-231 cells. Toxicon. 2013. 74, 56-67. Nov;74:56-67 (Epub 2013 Aug 7)

61.     Chao-Neng Tseng, Chien-Fu Huang, Chung-Lung Cho, Hsueh-Wei Chang, Chao-Wei Huang, Chien-Chih Chiu*, and Yung-Fu Chang*. Brefeldin A Effectively Inhibits Cancer Stem Cell Properties and MMP-9 Activity in Human Colorectal Cancer Colo 205 cells. “Molecules”. 2013. 18, 10242-10253 Aug 22. PMID: 23973996

62.     Hsing-Hui Li, Jui-Hsin Su Su@, Chien-Chih, Chiu@, Jen-Jie Lin, Zih-Yan Yang, Wen-Ing Hwang, Yu-Kuei Chen, Yu-Hsuan Lo, Yu-Jen Wu*. Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade (@ contributed equally). ”Marine Drugs”. 2013, 11(7), 2625-2642; IF:3.978. Jul 22 PMID: 23880933

63.     Chien-Chih Chiu, Jo-Wen Huang, Fang-Rong Chang, Kuang-Jing Huang, Hsuan-Min Huang, Hurng-Wern Huang, Chon-Kit Chou, Yang-Chang Wu, Hsueh-Wei Chang*. Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways. PLoS ONE. 2013; 8(5): e64739. May 21 PMID: 23705007

64.     Hsin-Yu Fang, Hui-Min Wang, Kuo-Feng Chang, Huei-Ting Hu, Lian-Je Hwang, Tzu-Fun Fu, Yin-Chieh Lin, Wei-Chiao Chang, Tsu-Pei Chiu, Zhi-Hong Wen, Chien-Chih Chiu*, Bing-Hung Chen* Feruloyl-L-arabinose attenuates migration, invasion and production of reactive oxygen species in H1299 lung cancer cells. Food and Chemical Toxicology. 2013. 58:496-466.PMID:23707472. Aug 1

65.     Ching-Yu Yen, Shih-Shin Liang, Lo-Yi Han, Han-Lin Chou, Chon-Kit Chou, Shinne-Ren Lin*, Chien-Chih Chiu*. Cardiotoxin III Inhibits Proliferation and Migration of Oral Cancer Cells through MAPK and MMP Signaling. The Scientific World Journal. 2013. e650946. IF:1.73. (April 8) PMCID: PMC3654281

66.     Chih-Chen Lee, Chien-Chih Chiu, Wei-Ting Liao, Pei-Fang Wu, Yi-Ting Chou, Kuo-Chuan Huang, Yen-Ting Chen, Zhi-Hong Wen and Hui-Min Wang*. Alpinia oxyphylla Miq. bioactive extracts from supercritical fluid carbon dioxide extraction. Biochemical Engineering Journal. 2013.78:101-107 Volume 78, (Sep 15) .

67.     Joel Stocker, Hurng-Wern Huang, Hong-Ming Wang, Hsueh-Wei Chang, Chien-Chih Chiu, Chung-Lung Cho, and Chao-Neng Tseng. Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock. “Kaohsiung Medical Science”. 2013. 29(9): 478-483. PMID: 24018150

68.     Wen ling Chan, Chung Yee Yuo, Wen uang Yang, Shih Huang, Ya Ian Chang, Chien-Chih Chiu, Kun Tu Yeh, Hsien Huang, Jan Jowth Chang. Transcribed pseudogene ψPPM1K generates endogenous  siRNA to suppress oncogenic cell growth in hepatocellular carcinoma. Nucleic Acid Research. 2013.41(6):3734-47. PMID: 23376929

69.     Yu-Lun Lo, Kuo-Hsun Sung, Chien-Chih Chiu and Li-Fang Wang. Chemically Conjugating Polyethylenimine with Chondroitin Sulfate to Promote CD44-Mediated Endocytosis for Gene Delivery. Molecular Pharmaceutics. 2013. 10(2):664-676. Feb 4. PMID: 23281918

70.     Wei-Fan Chiang, Tzer-Zen Hwang, Tzyh-Chyuan Hour, Lee-Hsin Wang, Chien-Chih Chiu, Hau-Ren Chen, Yu-Jen Wu, Chih-Chun Wang, Ling-Feng Wang, Chen-Yu Chien, Jen-Hao Chen, Chao-Tien Hsu, Jeff Yi-Fu Chen. Calreticulin, an endoplasmic reticulum-resident protein, is highly expressed and essential for cell proliferation and migration in oral squamous cell carcinoma. Oral Oncology. 2013. 49(6): 534-541. (Jun) PMID: 23375593

71.     Wei-Chun Chen, Sheng-Yang Wang, Chien-Chih Chiu, Chin-Kai Tseng, Hui-Chun Wang, and Jin-Ching Lee. Lucidone Suppresses Hepatitis C Virus Replication by Nrf2-Mediated Heme Oxygenase-1 Induction. Antimicrobial Agents and Chemotherapy. 2013. 57(3): 1180-1191.

72.     Chen, Chung-Yi; Chiu, Chien-Chih; Wu, Chi-Peng; Chou, Yi-Ting; Wang, Hui-Min. Enhancements on skin cell proliferations and migrations via 6-dehydrogingerdione. Journal of Agricultural and Food Chemistry. 2013. 61(6) 1349-1356.

 

Conferences 

·       Han-Lin Chou, Hurng-Wern Huang, Chien-Chih Chiu*. Chloroquine synergistically promotes C2-ceramide induced apoptosis of non-small cell lung cancer cells via inhibiting sirt1 expression. 2013 Taiwan Zebrafish Symposium Dec. 7. Institute of Biomedical Sciences Academia Sinica. #P22. (The best poster award).  台灣斑馬魚研討會 

·       Mei-Jei Lu and Chien-Chih Chiu*. The effect of Akt-targeting compounds on proliferation and apoptosis of lung cancer cells in zebrafish xenografts. 2013 Taiwan Zebrafish Symposium Dec. 7. Institute of Biomedical Sciences Academia Sinica.#P23. 台灣斑馬魚研討會

·       Chien Chih, Chiu and  Bing-Hung Chen*. Anti-allergic activity of grape seed extract (GSE) on RBL-2H3 mast cells. The 19th Symposium of Young Asian Biochemical Engineer’s Community (YABEC). (ORAL#1). 2013. Urumqi, China.

·       Chon Kit, Chou, Chien Chih, Chiu*. The 19th Symposium of Young Asian Biochemical Engineer’s Community (YABEC). (POSTER#PD1). YABEC 2013. Urumqi, China. (YABEC *best poster award)
Han Lin, Chou, Chien Chih, Chiu*. The 19th Symposium of Young Asian Biochemical Engineer’s Community (YABEC). (POSTER#PD2). 2013. Urumqi, China. 

·       Yin-Chieh Lin, Jeff Yi-Fu Chen, Chien-Chih Chiu*. The inhibitory effects of sirtinol, a sirtuin inhibitor on invasion of non-small cell lung cancer cells via Src signaling. The 18th Symposium of Young Asian Biochemical Engineer’s Community (YABEC) 2012. (ORAL: O-CD-7).

·       Pin-Hsuan Wu, Jeff Yi-Fu Chen, Yeh-Long Chen, Chien-Chih Chiu*. Naphtho[1,2-b] furan-4,5-dione, a naphthoquinone derivative induces anti-cell growth and anti-migration in non-small cell lung cancer by inhibiting topoisomerase II. Bio-IT WORLD ASIA in Marina Bay Sands Hotel, Singapore, in June 6-8, 2012.(*corresponding). (POSTER #6) Session of Drug Discovery and Bioinformatics.

·       Yuli C. Chang, Shih-Ya Hung, Chien-Chih Chiu, Wen-Lin Chan, Wen-Hsin Chang, Shou-Mei Wu, Ya-Sian Chang, Chung-Yee Yuo, Ta-Chih Liu, Wen-Kuang Yang, Jan-Gowth Chang*. Participation of a XIST-related small RNA in the formation of the K-RAS G-quadruplex. Non-Coding RNAs (Z1) Keystone symposia conference. Snowbird, Utah, USA, in March 31-April 5. 2012

·       Yin-Chieh Lin, Han-Lin Chou, Chien-Chih Chiu＊. The inhibitory effects of sirtuin1 inhibitor, sirtinol on migration and anchorage independent growth of lung cancer cells. (POSTER #85) SCMB2012. 第20 屆細胞及分子生物新知研討會 (*corresponding)

·       Han-Lin Chou, Feng-Wei Chen, Xin-Ping Tang, Hurng-Wern Huang＊, Chiu, Chien-Chih＊. The synergistic effect of C2-ceramide in Doxorubicin was induced senescence of non-small-cell lung cancer (NSCLC). (POSTER #57) SCMB2012. 第20 屆細胞及分子生物新知研討會 (*corresponding)

·       Chon Kit Chou, Han-Lin Chou, Feng-Wei Chen, Chien-Chih Chiu*.The Novel Function of BubR1 in Migration Ability of Non-Small Cell Lung Cancer Cells. (POSTER #121) SCMB2012. 第20 屆細胞及分子生物新知研討會(*corresponding)

·       Huei-Ting Hu, Hsueh-Wei Chang*, Lian-Je Hwang, Hsin-Yu Fang, Chien-Chih Chiu*. Effect of ferulic acid on anti-oxidation and cell proliferation of human lung cancer cells. (POSTER #95) SCMB 2012. 第20 屆細胞及分子生物新知研討會. (*corresponding)

·       Pin-Hsuan Wu, Chien-Chih Chiu*, Yeh-Long Chen, Hsueh-Wei Chang. A novel naphthoquinone derivative-induced apoptosis and growth inhibition of human non-small cell lung cancer (NSCLC). (POSTER #27) SCMB2012. 第20 屆細胞及分子生物新知研討會. (*corresponding)

·       Chiu-Chien Chiu*, Chon-Kit Chou, Han-Lin Chou. Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis and reduced migration ability. (Oral and POSTER) (POSTER # F14). The 17th Symposium of Young Asian Biochemical Engineer’s Community (YABEC) in Incheon, Korea in Oct 7-9,2011. (*corresponding)

·       Kuo-Feng Chang, Hsueh-Wei Chang, Tso-Wen Wang, Chih-Hua Tseng, Yeh-Long Chen, Chien-Chih Chiu*. The mechanistic study of quinoline-derivative-induced apoptosis and growth inhibition of lung cancer.(POSTER #160) SCMB 2011. 第19屆細胞及分子生物新知研討會. (*corresponding)

·       Kuo-Feng Chang, Hsueh-Wei Chang, Wan-Ju Chou, Chih-Hua Tseng, Yeh-Long Chen, Chien-Chih Chiu*. The quinoline-derivative DFIQ induced apoptosis and growth inhibition of lung cancer. SCMB 2011. 第19屆細胞及分子生物新知研討會. (*corresponding)

·       Han-Lin Chou, Hsueh-Wei Chang, Pi-Chuan Hsieh, Xin-Ping Tang, Feng-Wei Chen, Hurng-Wern Huang*,Chiu, Chien-Chih*. Role of exogenous ceramides in modulating the expression of human type III deacetylase SIRT-1 and SIRT-2 of human non-small cell lung cancer (NSCLC) cells. (POSTER #86) SCMB 2011.第19屆細胞及分子生物新知研討會. (*corresponding)

·       Yin-Chieh Lin, Jeff Yi-Fu Chen, Hsueh-Wei Chang*, Chien-Chih Chiu*. The modulation of cell proliferation induced by exogenous ceramide in human breast cancer cells. (POSTER #114) SCMB 2011. 第19屆細胞及分子生物新知研討會. (*corresponding)

·       Huei-Ting Hu, Hsueh-Wei Chang, Lian-Je Hwang, Hsin-Yu Fang, Chien-Chih Chiu*. Effect of feruloyl xylo-oligosaccharides on antioxidant activity and cell migration in human lung cancer H1299 cells. (POSTER #133) SCMB 2011. 第19屆細胞及分子生物新知研討會. (*corresponding)

·       Pin-Hsuan Wu, Chien-Chih Chiu*, Yeh-Long Chen and Hsueh-Wei Chang*. NFD inhibits cell proliferation and migration of human non-small cell lung cancer (NSCLC) cell through DNA damage and reduced migration ability. (POSTER #50) SCMB 2011. 第19 屆細胞及分子生物新知研討會. (*corresponding)

·       Chon-kit Chou, Han-Lin Chou, Pin-Hsuan Wu, Hsueh-Wei Chang* and Chien-Chih Chiu*. The effect of spindle assembly checkpoint kinase BubR1 on cellular migration in oral squamous cell carcinoma. (POSTER #171) SCMB 2011. 第19 屆細胞及分子生物新知研討會. (*corresponding)

·       Kuang-Jing Huang, Chien-Chih Chiu*, Fang-Rong Chang, Yang-Chang Wu, Hsueh-Wei Chang*. AN10 is a potential natural product-derived drug against oral cancer. SCMB 2011. 第19 屆細胞及分子生物新知研討會.(*corresponding)

·       Kuang-Jing Huang, Chien-Chih Chiu*, Fang-Rong Chang, Yang-Chang Wu, Hsueh-Wei Chang*. AN10 inhibits growth of human lung cancer cells through DNA damage, apoptosis and reduced migration ability. (POSTER #256) SCMB 2011. 第19屆細胞及分子生物新知研討會. (*corresponding)

·       Kuang-Jing Huang, Chien-Chih Chiu*, Fang-Rong Chang, Yang-Chang Wu, Hsueh-Wei Chang*. SCMB 2011. AN37 is a potential natural product-derived drug against oral cancer.第19屆細胞及分子生物新知研討會.

·       Jeff Yi-Fu Chen, Chien-Chih Chiu, Yu-Jen Wu, Hau-Ren Chen. Betel Quid Extract Promotes Oral Cancer Cell Migration by Activating a Muscarinic M4 Receptor-Mediated Signaling Cascade Involving ERK1/2 and SFKs. 4th World Congress of International Federation of Head and Neck Oncologic Societies in Seoul, Korea in June 15-19, 2010.

·       Guang-Jing Huang, Ming-Tz Tsai, Chon-Kit Chou, Chien-Chih Chiu, Yang-Chang Wu, Hsueh-Wei Chang. Growth inhibition of lung cancer cell using herb-derived compound AN10 based on cell migration analysisSCMB 2010. 第18屆分子生物學會冬令營

·       Yung-Lan Su, Yi-Han Lo, Wan-Yu Chen, Tsung-Lun Kuo, Jan-Gowth Chang*, Chien-Chih Chiu*.Characterization of ectopic expression of nuclear export factor (NXF) in human hepatoma cells Huh-7 (POSTER # P331) The Twenty-fourth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan. (Mar. 21-22, 2009). 第24屆生物醫學聯合學術年會 (*corresponding)

·       Chien-Chih Chiu* (Oral Presentation # O46 ). Effects of ectopically expressed nuclear export factor (NXF) on cell migration and adhesion in human hepatoma cells. The Twenty-fourth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar. 21-22, 2009. 第24屆生物醫學聯合學術年會 (*oral and corresponding)

·       Pi-Chuan Hsieh, Chien-Chih, Chiu, Jan-Gowth Chang, Sheng-Fung Lin.BubR1 Gene Is Involved in Ceramide Induced Mitotic Arrest in Malignant Cancer Cells.(May 2007). 第12屆台灣癌症聯合學術年會

·       Ying-Chieh Chu, Kai-Li Su, Min-Tsui Wu, Chien-Chih Chiu*. The effects of caffeic acid in anticancer drug-induced human non-small cell lung cancer (NSCLC) cells. (Mar 2007). 第22屆生物醫學年會 (*corresponding)

 

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