wang-ch

 

 

聯絡方式: 

  • 辦公室: 第一教學大樓N1021室
  • 實驗室: 第一教學大樓N1020室
  • 電話: (07) 3121101 ext. 2699
  • 傳真: (07) 3125339
  • 電子郵件: chwang@kmu.edu.tw

 

學經歷:

  • 中興大學植物病理系農學士 ()
  • 國立清華大學生命科學研究所碩士 ()
  • 美國威斯康辛大學麥迪遜分校哲學博士 ()
  • 高雄醫學大學生物科技學系系主任 (2009/08 - 2012/07)

 

主負責授課科目:

  • 生物科技導論
  • 藥物開發
  • 英文科學期刊選讀與報告之撰寫
  • 遺傳學

 

研究興趣:

  • Cancer drug discovery
  • Molecular carcinogenesis of prostate cancer
  • DNA repair and cell cycle control
  • Molecular pathway of adipogenesis

 

近期研究成果:

  • Sack J, Kish K, Wang C, Attar R, Kiefer S, An Y, Wu G, Scheffler J, Salvati M, Krystek S, weinmann R, and Einspahr H. Crystallographic Structures of ligand-binding domain of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone. PNAS 98: 4904-4909, (2001).
  • Howng SL, Wu CH, Cheng TS, Sy WD, Lin PC, Wang C and Hong YR. Differential expression of Wnt genes, beta-catenin and E-cadherin in human brain tumors. Cancer Lett 183 (1): 95-101 (2002).
  • Chihuei Wang, Fan Yeung, Po-Chun Liu, Ricardo M. Attar, Jieping Geng, Leland W. K. Chung, Marco Gottardis, and Chinghai Kao. Identification of a Novel Transcription Factor, GAGATA-binding Protein, Involved in Androgen-mediated Expression of Prostate-specific Antigen.  J. Biol. Chem. 278, 32423-32430 (2003).
  • Howng SL, Sy WD, Cheng TS, Lieu AS, Wang C, Tzou WS, Cho CL, Hong YR. Genomic organization, alternative splicing, and promoter analysis of human dynamin-like protein gene. Biochem Biophys Res Commun. 314(3):766-72 (2004).
  • Huang CL, Cheng JC, Liao CH, Stern A, Hsieh JT, Wang CH, Hsu HL, Tseng CP. Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling. J Biol Chem. 279(40):42279-89. (2004).
  • Howng SL, Huang FH, Hwang SL, Lieu AS , Sy WD, Wang C, Hong YR. Differential expression and splicing isoform analysis of human Tcf-4 transcription factor in brain tumors. Int J Oncol 25(6):1685-92 (2004).
  • Balog A, Salvati ME, Shan W, Mathur A, Leith LW, Wei DD, Attar RM, Geng J, Rizzo CA, Wang C, Krystek SR, Tokarski JS, Hunt JT, Gottardis M, Weinmann R. The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists. Bioorg Med Chem Lett. 14(24):6107-11. (2004).
  • Jung C, Kim RS, Lee SJ, Wang C, Jeng MH. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. Cancer Res. 64(9):3046-51. (2004).
  • Po-Jen Chen, Chi-Chen Wei, Chihuei Wang, Feng-Wei Chen, Yu-Hsiang Hsu and Ming-Shi Chang. Promoter analysis of interleukin 19. Biochem Biophys Res Commun. (2006) 344(3):713-720.
  • Hui-Ting Hsu, Po-Chun Liu, Sheng-Yu Ku, Kuo-Chen Jung, Yi-Ren Hong, Chinghai Kao and Chihuei Wang. ?-Catenin control of T-cell transcription factor 4 (Tcf4) importation from the cytoplasm to the nucleus contributes to Tcf4-mediated transcription in 293 cells. Biochem Biophys Res Commun. 343(3):893-8 (2006).
  • Chihuei Wang, Grace Lee, Wayne Hsu, Ching-Hua Yeh, Mei-Ling Ho and Gwo-Jaw Wang. (2006) Identification of USF2 as a Key Regulator of RUNX2 Expression in Mouse Pluripotent Mesenchymal D1 Cells. Mol. Cell. Biochem. 292(1-2):79-88 (2006).
  • Shu-Yu Lia,Yeh-Long Chen, Chihuei Wang, and Cherng-Chyi Tzenga*. Synthesis and antiproliferative evaluation of certain pyrido[3,2-g]quinoline derivatives. Bioorganic & Medical Chemistry. 14(22):7370-6 (2006).
  • He-Yen Chou, Shen-Long Howng, Tai-Shan Cheng, Yun-ling Hsiao, Ann-Shung Lieu, Joon-Khim Loh, Shiuh-Lin Hwang, Ching-Chih, Ching-Mei Hsu, Chihuei Wang, Chu-I Lee, Pei-Jung Lu, Chen-Kung Chou, Chi-Ying Huang and Yi-Ren Hong.. GSKIP, shares a homology of Axin GID domain and functions as a negative regulator of GSK3beta. Biochemistry.  45(38):11379-89 (2006).
  • Shao-Hung Hung, Ching-Hua Yeh, Hsuan-Ti Huang, Peihua Wu, Mei-Ling Ho, Chung-Hwan Chen, Chihuei Wang, David Chao, Gwo-Jaw Wang. Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line, but not through the peroxisome proliferator-activated receptor-γ pathway. Life Sciences 82: 561–569 (2008).
  • Chung-Hwan Chen, Jian-Chih Chen, Chihuei Wang, Yin-Chun Tien, Je-Ken Chang and Shao-Hung Hung. Semitubular Plates for Acutely Displaced Midclavicular Fractures: A Retrospective Study of 111 Patients Followed for 2.5 to 6 Years. J Orthop Trauma 22:463–466 (2008).

 

其他研究成果:

Patent:

  1. Patent 7225083 “Crystallographic structure of the androgen receptor ligand binding domain”
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